HSP990, 99%, a potent and selective Hsp90 inhibitor, with IC50 values of 0.6, 0.8, and 8.5 nM for Hsp90α, Hsp90β, and Grp94, respectively

Name: HSP990, 99%, a potent and selective Hsp90 inhibitor, with IC50 values of 0.6, 0.8, and 8.5 nM for Hsp90α, Hsp90β, and Grp94, respectively | 934343-74-5
Brand: J&K Chemical
SKU: JK1761245_5_MG
Price: 29.2 USD
Availability: OutOfStock

Cat. No JK1761245_5_MG

Vendor: J&K Chemical

Product Information

Product Name

HSP990, 99%, a potent and selective Hsp90 inhibitor, with IC50 values of 0.6, 0.8, and 8.5 nM for Hsp90α, Hsp90β, and Grp94, respectively

Brand Name

J&K

Product Number

1761245

CAS

934343-74-5

SDS Document

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Certificate of Analysis (COA)

COA not found

General Information

PubChem CID

46216556

IUPAC Name

(7R)-2-amino-7-4-fluoro-2-(6-methoxy-2-pyridinyl)phenyl-4-methyl-7,8-dihydro-6H-pyrido4,3-dpyrimidin-5-one

InChI Key

WSMQUUGTQYPVPD-OAHLLOKOSA-N

SMILES

CC1=C2C(=NC(=N1)N)CC@@H(NC2=O)C3=C(C=C(C=C3)F)C4=NC(=CC=C4)OC

Safety Information

Storage Condition

Freezer -20℃

References Data Source From Pubchem

[11C]HSP990 PET as a translational tool to investigate the role of Hsp90 in tumours and support the development of Hsp90 therapeutics

Publication Name: EJNMMI Radiopharmacy and Chemistry

Publication Date: 2025-09-26

DOI: 10.1186/s41181-025-00386-z

Structural Insights into Selectively Targeting Candida albicans Hsp90

Publication Name: Biochemistry

Publication Date: 2025-05-21

DOI: 10.1021/acs.biochem.5c00015

High-Throughput Screening to Identify Inhibitors of the Type I Interferon–Major Histocompatibility Complex Class I Pathway in Skeletal Muscle

Publication Name: ACS Chemical Biology

Publication Date: 2020-05-27

DOI: 10.1021/acschembio.0c00343

New TRAP1 and Hsp90 chaperone inhibitors with cationic components: Preliminary studies on mitochondrial targeting

Publication Name: Bioorganic & Medicinal Chemistry Letters

Publication Date: 2018-07-15

DOI: 10.1016/j.bmcl.2018.05.031

Regulating the master regulator: Controlling heat shock factor 1 as a chemotherapy approach

Publication Name: Bioorganic & Medicinal Chemistry Letters

Publication Date: 2015-09-01

DOI: 10.1016/j.bmcl.2015.06.052

HSP990, 99%, a potent and selective Hsp90 inhibitor, with IC50 values of 0.6, 0.8, and 8.5 nM for Hsp90α, Hsp90β, and Grp94, respectively

Product Information

General Information

Safety Information

References Data Source From Pubchem

[11C]HSP990 PET as a translational tool to investigate the role of Hsp90 in tumours and support the development of Hsp90 therapeutics

Structural Insights into Selectively Targeting Candida albicans Hsp90

High-Throughput Screening to Identify Inhibitors of the Type I Interferon–Major Histocompatibility Complex Class I Pathway in Skeletal Muscle

New TRAP1 and Hsp90 chaperone inhibitors with cationic components: Preliminary studies on mitochondrial targeting

Regulating the master regulator: Controlling heat shock factor 1 as a chemotherapy approach