GSK2606414, 99%, a cell-permeable and orally available PERK inhibitor

Name: GSK2606414, 99%, a cell-permeable and orally available PERK inhibitor | 1337531-36-8
Brand: J&K Chemical
SKU: JK1578772_2_MG
Price: 51.4 USD
Availability: OutOfStock

Cat. No JK1578772_2_MG

Vendor: J&K Chemical

Product Information

Product Name

GSK2606414, 99%, a cell-permeable and orally available PERK inhibitor

Brand Name

J&K

Product Number

1578772

CAS

1337531-36-8

SDS Document

View/Download

Certificate of Analysis (COA)

COA not found

General Information

PubChem CID

53469448

IUPAC Name

1-5-(4-amino-7-methylpyrrolo2,3-dpyrimidin-5-yl)-2,3-dihydroindol-1-yl-2-3-(trifluoromethyl)phenylethanone

InChI Key

SIXVRXARNAVBTC-UHFFFAOYSA-N

SMILES

CN1C=C(C2=C(N=CN=C21)N)C3=CC4=C(C=C3)N(CC4)C(=O)CC5=CC(=CC=C5)C(F)(F)F

Safety Information

Storage Condition

Freezer -20℃

References Data Source From Pubchem

Trimethylamine N-oxide induces non-alcoholic fatty liver disease by activating the PERK

Publication Name: Toxicology Letters

Publication Date: 2024-10

DOI: 10.1016/j.toxlet.2024.08.009

Tetrahydrocurcumin Attenuates Polymyxin B Sulfate‐Induced HK ‐2 Cells Apoptosis by Inhibiting Endoplasmic Reticulum Stress‐Mediated PERK / eIF2α / ATF4 / CHOP Signaling Pathway Axis

Publication Name: Environmental Toxicology

Publication Date: 2024-07-18

DOI: 10.1002/tox.24376

Mitochondrial dysfunction and endoplasmic reticulum stress induced by activation of PPARα leaded testicular to apoptosis in SD rats explored to di-(2-ethylhexyl) phthalate (DEHP)

Publication Name: Ecotoxicology and Environmental Safety

Publication Date: 2023-12

DOI: 10.1016/j.ecoenv.2023.115711

Caspase-3/GSDME dependent pyroptosis contributes to offspring lung injury induced by gestational PFOS exposure via PERK/ATF4 signaling

Publication Name: Archives of Toxicology

Publication Date: 2023-11-13

DOI: 10.1007/s00204-023-03626-w

BLM overexpression as a predictive biomarker for CHK1 inhibitor response in PARP inhibitor–resistant BRCA -mutant ovarian cancer

Publication Name: Science Translational Medicine

Publication Date: 2023-06-21

DOI: 10.1126/scitranslmed.add7872

GSK2606414, 99%, a cell-permeable and orally available PERK inhibitor

Product Information

General Information

Safety Information

References Data Source From Pubchem

Trimethylamine N-oxide induces non-alcoholic fatty liver disease by activating the PERK

Tetrahydrocurcumin Attenuates Polymyxin B Sulfate‐Induced HK ‐2 Cells Apoptosis by Inhibiting Endoplasmic Reticulum Stress‐Mediated PERK / eIF2α / ATF4 / CHOP Signaling Pathway Axis

Mitochondrial dysfunction and endoplasmic reticulum stress induced by activation of PPARα leaded testicular to apoptosis in SD rats explored to di-(2-ethylhexyl) phthalate (DEHP)

Caspase-3/GSDME dependent pyroptosis contributes to offspring lung injury induced by gestational PFOS exposure via PERK/ATF4 signaling

BLM overexpression as a predictive biomarker for CHK1 inhibitor response in PARP inhibitor–resistant BRCA -mutant ovarian cancer