A 769662, 98%, a potent, reversible AMPK activator with EC50 of 0.8 μM

Name: A 769662, 98%, a potent, reversible AMPK activator with EC50 of 0.8 μM | 844499-71-4
Brand: J&K Chemical
SKU: JK1386067_10_MG
Price: 121.0 USD
Availability: OutOfStock

Cat. No JK1386067_10_MG

Vendor: J&K Chemical

Product Information

Product Name

A 769662, 98%, a potent, reversible AMPK activator with EC50 of 0.8 μM

Brand Name

J&K

Product Number

1386067

CAS

844499-71-4

SDS Document

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Certificate of Analysis (COA)

COA not found

General Information

PubChem CID

54708532

IUPAC Name

4-hydroxy-3-4-(2-hydroxyphenyl)phenyl-6-oxo-7H-thieno2,3-bpyridine-5-carbonitrile

InChI Key

CTESJDQKVOEUOY-UHFFFAOYSA-N

SMILES

C1=CC=C(C(=C1)C2=CC=C(C=C2)C3=CSC4=C3C(=C(C(=O)N4)C#N)O)O

Safety Information

Storage Condition

Store at 2-8℃

References Data Source From Pubchem

AMPK as a central regulator of metabolic memory: mechanisms and therapeutic opportunities

Publication Name: Journal of diabetes and metabolic disorders

Publication Date: 2026-01-20

DOI: 10.1007/s40200-026-01859-x

The thienopyridine A-769662 and benzimidazole 991 inhibit human TASK-3 potassium channels in an AMPK-independent manner

Publication Name: Biochemical Pharmacology

Publication Date: 2024-12

DOI: 10.1016/j.bcp.2024.116562

Alcohol induces p53-mediated apoptosis in neural crest by stimulating an AMPK-mediated suppression of TORC1, S6K, and ribosomal biogenesis

Publication Name: Reproductive toxicology (Elmsford, N.Y.)

Publication Date: 2024-12

DOI: 10.1016/j.reprotox.2024.108747

Targeting autophagy with small-molecule activators for potential therapeutic purposes

Publication Name: European Journal of Medicinal Chemistry

Publication Date: 2023-11-15

DOI: 10.1016/j.ejmech.2023.115722

Drug combinations identified by high-throughput screening promote cell cycle transition and upregulate Smad pathways in myeloma

Publication Name: Cancer Letters

Publication Date: 2023-08-01

DOI: 10.1016/j.canlet.2023.216284

A 769662, 98%, a potent, reversible AMPK activator with EC50 of 0.8 μM

Product Information

General Information

Safety Information

References Data Source From Pubchem

AMPK as a central regulator of metabolic memory: mechanisms and therapeutic opportunities

The thienopyridine A-769662 and benzimidazole 991 inhibit human TASK-3 potassium channels in an AMPK-independent manner

Alcohol induces p53-mediated apoptosis in neural crest by stimulating an AMPK-mediated suppression of TORC1, S6K, and ribosomal biogenesis

Targeting autophagy with small-molecule activators for potential therapeutic purposes

Drug combinations identified by high-throughput screening promote cell cycle transition and upregulate Smad pathways in myeloma