A 769662, 98%, a potent, reversible AMPK activator with EC50 of 0.8 μM

Name: A 769662, 98%, a potent, reversible AMPK activator with EC50 of 0.8 μM | 844499-71-4
Brand: J&K Chemical
SKU: JK1386067_10_MG
Price: 121.0 USD
Availability: OutOfStock

Cat. No JK1386067_10_MG

Vendor: J&K Chemical

Product Information

Product Name

A 769662, 98%, a potent, reversible AMPK activator with EC50 of 0.8 μM

Brand Name

J&K

Product Number

1386067

CAS

844499-71-4

SDS Document

View/Download

Certificate of Analysis (COA)

COA not found

General Information

PubChem CID

54708532

IUPAC Name

4-hydroxy-3-4-(2-hydroxyphenyl)phenyl-6-oxo-7H-thieno2,3-bpyridine-5-carbonitrile

InChI Key

CTESJDQKVOEUOY-UHFFFAOYSA-N

SMILES

C1=CC=C(C(=C1)C2=CC=C(C=C2)C3=CSC4=C3C(=C(C(=O)N4)C#N)O)O

Safety Information

Storage Condition

Store at 2-8℃

References

Activating AMPK improves pathological phenotypes due to mtDNA depletion

Publication Name: The FEBS Journal

Publication Date: 2025-02-07

DOI: 10.1111/febs.70006

Hypoglycaemic stimulation of macrophage cytokine release is suppressed by <scp>AMP</scp>‐activated protein kinase activation

Publication Name: Diabetic medicine : a journal of the British Diabetic Association

Publication Date: 2024-12-24

DOI: 10.1111/dme.15456

The thienopyridine A-769662 and benzimidazole 991 inhibit human TASK-3 potassium channels in an AMPK-independent manner

Publication Name: Biochemical Pharmacology

Publication Date: 2024-12

DOI: 10.1016/j.bcp.2024.116562

Alcohol induces p53-mediated apoptosis in neural crest by stimulating an AMPK-mediated suppression of TORC1, S6K, and ribosomal biogenesis

Publication Name: Reproductive toxicology (Elmsford, N.Y.)

Publication Date: 2024-12

DOI: 10.1016/j.reprotox.2024.108747

The AMPK allosteric activator MK ‐8722 improves the histology and spliceopathy in myotonic dystrophy type 1 ( DM1 ) skeletal muscle

Publication Name: FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Publication Date: 2024-11-29

DOI: 10.1096/fj.202401145rr

A 769662, 98%, a potent, reversible AMPK activator with EC50 of 0.8 μM

Product Information

General Information

Safety Information

References

Activating AMPK improves pathological phenotypes due to mtDNA depletion

Hypoglycaemic stimulation of macrophage cytokine release is suppressed by <scp>AMP</scp>‐activated protein kinase activation

The thienopyridine A-769662 and benzimidazole 991 inhibit human TASK-3 potassium channels in an AMPK-independent manner

Alcohol induces p53-mediated apoptosis in neural crest by stimulating an AMPK-mediated suppression of TORC1, S6K, and ribosomal biogenesis

The AMPK allosteric activator MK ‐8722 improves the histology and spliceopathy in myotonic dystrophy type 1 ( DM1 ) skeletal muscle