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Sku CI02465_25_G
Chem Impex
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Product Information

Product Name
Fmoc-O-tert-butyl-D-tyrosine
Brand Name
Chem Impex
Product Number
02465
CAS
118488-18-9
Certificate of Analysis (COA)​
COA not found

General Information

PubChem CID
12968135
IUPAC Name
(2R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-4-(2-methylpropan-2-yl)oxyphenylpropanoic acid
InChI Key
JAUKCFULLJFBFN-RUZDIDTESA-N
SMILES
CC(C)(C)OC1=CC=C(C=C1)CC@H(C(=O)O)NC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24

Application

Fmoc-O-tert-butyl-D-tyrosine is widely utilized in research focused on:

Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, particularly in solid-phase peptide synthesis (SPPS). Its protective groups allow for selective reactions, enhancing the efficiency of peptide assembly.

Drug Development: In pharmaceutical research, it is used to create peptide-based drugs. The stability and solubility provided by its structure can lead to more effective therapeutic agents.

Bioconjugation: The chemical is valuable in bioconjugation processes, where it helps attach peptides to other biomolecules, improving the delivery and efficacy of drugs in targeted therapies.

Research in Neuroscience: Fmoc-O-tert-butyl-D-tyrosine is used in studies related to neuropeptides, aiding in the understanding of neurological pathways and potential treatments for neurodegenerative diseases.

Custom Peptide Libraries: It is instrumental in creating diverse peptide libraries for screening in drug discovery, allowing researchers to identify potential leads more efficiently.

References Data Source From Pubchem

Rapid clearance of achiral small-molecule drugs using de novo-designed proteins and their cyclic and mirror-image variants

Publication Name: Nature Biomedical Engineering
Publication Date: 2025-05-29
DOI: 10.1038/s41551-025-01404-w

Identification of a Mirror-Image VHH Against Vascular Endothelial Growth Factor

Publication Name: Development of Mirror-Image VHHs with Less Immunogenicity
Publication Date: 2025
DOI: 10.1007/978-981-96-1301-4_3

In-solution enrichment identifies peptide inhibitors of protein–protein interactions

Publication Name: Nature Chemical Biology
Publication Date: 2019-03-18
DOI: 10.1038/s41589-019-0245-2

Identification of noncovalent proteasome inhibitors with high selectivity for chymotrypsin-like activity by a multistep structure-based virtual screening

Publication Name: European Journal of Medicinal Chemistry
Publication Date: 2016-10-04
DOI: 10.1016/j.ejmech.2016.05.049

In Silico and NMR Identification of Inhibitors of the IGF-I and IGF-Binding Protein-5 Interaction

Publication Name: Journal of Medicinal Chemistry
Publication Date: 2002-11-23
DOI: 10.1021/jm0208828