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Chem Impex
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Product Information

Product Name
Fmoc-O-tert-butyl-L-tyrosine
Brand Name
Chem Impex
Product Number
00495
CAS
71989-38-3
Certificate of Analysis (COA)​
COA not found

General Information

PubChem CID
10895791
IUPAC Name
(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-4-(2-methylpropan-2-yl)oxyphenylpropanoic acid
InChI Key
JAUKCFULLJFBFN-VWLOTQADSA-N
SMILES
CC(C)(C)OC1=CC=C(C=C1)CC@@H(C(=O)O)NC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24

Application

Fmoc-O-tert-butyl-L-tyrosine is widely utilized in research focused on:

Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, particularly in solid-phase peptide synthesis (SPPS), allowing for the creation of complex peptide sequences efficiently.

Drug Development: It plays a significant role in pharmaceutical research, where it is used to develop peptide-based drugs, enhancing the bioavailability and stability of therapeutic agents.

Bioconjugation: The compound is utilized in bioconjugation processes, enabling researchers to attach biomolecules to drugs or imaging agents, which is crucial for targeted therapies and diagnostics.

Research in Neuroscience: Fmoc-O-tert-butyl-L-tyrosine is employed in studies related to neurotransmitter functions, helping scientists understand the role of tyrosine derivatives in brain chemistry.

Protein Engineering: It is used in the modification of proteins to study structure-function relationships, providing insights that can lead to the development of novel enzymes or therapeutic proteins.

References Data Source From Pubchem

A bioinformatics approach to design minimal biomimetic metal-binding peptides

Publication Name: Communications Chemistry
Publication Date: 2025-10-06
DOI: 10.1038/s42004-025-01702-z

Protolytic properties and biological activity of spinorphin and its butyric acid derivatives in aqueous solution

Publication Name: Amino Acids
Publication Date: 2025-09-18
DOI: 10.1007/s00726-025-03481-2

Exploring tunable characteristics of anthranilic acid in peptide-based nanostructures

Publication Name: Journal of Materials Research
Publication Date: 2025-09-02
DOI: 10.1557/s43578-025-01683-8

Discordance between in silico and in vitro results on proteolytic stability of milk protein-derived DPP-4 inhibitory peptides

Publication Name: European Food Research and Technology
Publication Date: 2025-07-09
DOI: 10.1007/s00217-025-04833-8

Stabilization of a miniprotein fold by an unpuckered proline surrogate

Publication Name: Communications Chemistry
Publication Date: 2025-03-12
DOI: 10.1038/s42004-025-01474-6