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Sku CI47394_250_MG
Chem Impex
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Product Information

Product Name
Fmoc-5-bromo-L-tryptophan
Brand Name
Chem Impex
Product Number
47394
CAS
460751-66-0
Certificate of Analysis (COA)​
COA not found

General Information

PubChem CID
21308672
IUPAC Name
(2S)-3-(5-bromo-1H-indol-3-yl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid
InChI Key
OAIIUHJPRPJYHV-DEOSSOPVSA-N
SMILES
C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)NC@@H(CC4=CNC5=C4C=C(C=C5)Br)C(=O)O

Description

Fmoc-5-bromo-L-tryptophan is widely utilized in research focused on:

Peptide Synthesis: This compound is an essential building block in the synthesis of peptides, particularly in solid-phase peptide synthesis (SPPS), allowing researchers to create complex peptides with specific sequences.

Drug Development: Its unique structure makes it valuable in medicinal chemistry for developing new pharmaceuticals, especially those targeting neurological disorders, due to the tryptophan moiety's role in serotonin production.

Bioconjugation: The bromo group allows for selective reactions, making it useful in bioconjugation techniques to attach biomolecules to surfaces or other molecules, enhancing drug delivery systems.

Fluorescent Probes: The Fmoc group can be utilized in creating fluorescent probes for biological imaging, providing insights into cellular processes and molecular interactions.

Research in Neuroscience: Its application in studying neurotransmitter pathways helps researchers understand mood regulation and the biochemical basis of depression and anxiety.

References Data Source From Pubchem

Pharmacophore variants of the macrocyclic peptide triazole inactivator of HIV-1 Env

Publication Name: Medicinal Chemistry Research
Publication Date: 2023-06-27
DOI: 10.1007/s00044-023-03092-0