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Sku CI02483_1_G
Chem Impex
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Product Information

Product Name
Fmoc-O-tert-butyl-D-threonine
Brand Name
Chem Impex
Product Number
02483
CAS
138797-71-4
Certificate of Analysis (COA)​
COA not found

General Information

PubChem CID
7021418
IUPAC Name
(2R,3S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(2-methylpropan-2-yl)oxybutanoic acid
InChI Key
LZOLWEQBVPVDPR-VBKZILBWSA-N
SMILES
CC@@H(C@H(C(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13)OC(C)(C)C

Application

Fmoc-O-tert-butyl-D-threonine is widely utilized in research focused on:

Peptide Synthesis: This compound serves as a protective group in the synthesis of peptides, allowing for the selective modification of amino acids without interfering with other functional groups. This is crucial for researchers developing new therapeutic peptides.

Drug Development: It is used in the design of peptide-based drugs, particularly in the pharmaceutical industry, where its stability and ease of removal make it a preferred choice for creating bioactive compounds.

Bioconjugation: The chemical is effective in bioconjugation processes, where it helps attach biomolecules to surfaces or other molecules, enhancing the functionality of diagnostic tools and therapeutics.

Protein Engineering: Researchers utilize it in the modification of proteins to study structure-function relationships, which is essential for developing new enzymes or antibodies with improved characteristics.

Research in Chemical Biology: It plays a role in chemical biology studies, where it aids in the exploration of cellular processes and interactions, helping scientists understand disease mechanisms and identify potential drug targets.

References Data Source From Pubchem

Rapid clearance of achiral small-molecule drugs using de novo-designed proteins and their cyclic and mirror-image variants

Publication Name: Nature Biomedical Engineering
Publication Date: 2025-05-29
DOI: 10.1038/s41551-025-01404-w