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Sku CI17432_1_G
Chem Impex
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Product Information

Product Name
2-(4-Trifluoromethyl-phenyl)thiazole-4-carboxylic acid
Brand Name
Chem Impex
Product Number
17432
CAS
144061-16-5
Certificate of Analysis (COA)​
COA not found

General Information

PubChem CID
2794766
IUPAC Name
2-4-(trifluoromethyl)phenyl-1,3-thiazole-4-carboxylic acid
InChI Key
NFDUVSSDGPDOLR-UHFFFAOYSA-N
SMILES
C1=CC(=CC=C1C2=NC(=CS2)C(=O)O)C(F)(F)F

Application

2-(4-Trifluoromethyl-phenyl)thiazole-4-carboxylic acid is widely utilized in research focused on:

Pharmaceutical Development: This compound serves as a key intermediate in the synthesis of various pharmaceuticals, particularly in the development of anti-inflammatory and antimicrobial agents.

Agricultural Chemistry: It is used in the formulation of agrochemicals, enhancing the effectiveness of pesticides and herbicides due to its unique chemical properties that improve target specificity.

Material Science: The compound is incorporated into polymers and coatings, providing improved thermal stability and chemical resistance, which is crucial for high-performance materials.

Biochemical Research: It acts as a valuable tool in studying biological pathways, especially in the context of enzyme inhibition and receptor binding studies, aiding in drug discovery.

Fluorine Chemistry: Its trifluoromethyl group enhances lipophilicity, making it useful in the design of novel compounds with improved pharmacokinetic properties, thus offering advantages over similar compounds.

References Data Source From Pubchem

In crystallo-screening for discovery of human norovirus 3C-like protease inhibitors

Publication Name: Journal of Structural Biology: X
Publication Date: 2020
DOI: 10.1016/j.yjsbx.2020.100031

Author response: An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering

Publication Name: eLife
Publication Date: 2018-06-07
DOI: 10.7554/elife.36307|10.7554/elife.36307.045