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Sku CI02482_100_G
Chem Impex
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Product Information

Product Name
Fmoc-O-tert-butyl-D-serine
Brand Name
Chem Impex
Product Number
02482
CAS
128107-47-1
Certificate of Analysis (COA)​
COA not found

General Information

PubChem CID
7004204
IUPAC Name
(2R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(2-methylpropan-2-yl)oxypropanoic acid
InChI Key
REITVGIIZHFVGU-LJQANCHMSA-N
SMILES
CC(C)(C)OCC@H(C(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13

Application

Fmoc-O-tert-butyl-D-serine is widely utilized in research focused on:

Peptide Synthesis: This compound is a key building block in the synthesis of peptides. Its protective groups facilitate the stepwise assembly of amino acids, making it easier for chemists to create complex peptide structures.

Drug Development: In pharmaceutical research, it helps in designing peptide-based drugs. The stability and solubility of the compound enhance the bioavailability of therapeutic peptides, crucial for effective drug formulation.

Bioconjugation: Fmoc-O-tert-butyl-D-serine is used in bioconjugation techniques, allowing researchers to attach biomolecules to surfaces or other molecules. This application is vital in creating targeted drug delivery systems.

Protein Engineering: It plays a significant role in modifying proteins to improve their functionality or stability. This is particularly important in the biotechnology sector, where engineered proteins can lead to better industrial enzymes or therapeutic proteins.

Research in Neuroscience: The compound is utilized in studies related to neuropeptides, which are important for understanding brain function and developing treatments for neurological disorders.

References Data Source From Pubchem

Rapid clearance of achiral small-molecule drugs using de novo-designed proteins and their cyclic and mirror-image variants

Publication Name: Nature Biomedical Engineering
Publication Date: 2025-05-29
DOI: 10.1038/s41551-025-01404-w

Identification of a Mirror-Image VHH Against Vascular Endothelial Growth Factor

Publication Name: Development of Mirror-Image VHHs with Less Immunogenicity
Publication Date: 2025
DOI: 10.1007/978-981-96-1301-4_3

In-solution enrichment identifies peptide inhibitors of protein–protein interactions

Publication Name: Nature Chemical Biology
Publication Date: 2019-03-18
DOI: 10.1038/s41589-019-0245-2

Synthesis and Biological Activity of N-Sulfonyltripeptides with C-Terminal Arginine as Potential Serine Proteases Inhibitors

Publication Name: International Journal of Peptide Research and Therapeutics
Publication Date: 2012-12-02
DOI: 10.1007/s10989-012-9338-4

Effects of Tripeptides on the Amidolytic Activities of Urokinase, Thrombin, Plasmin and Trypsin

Publication Name: International Journal of Peptide Research and Therapeutics
Publication Date: 2008-06-03
DOI: 10.1007/s10989-008-9132-5