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Chem Impex
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Product Information

Product Name
L-a-Methylproline
Brand Name
Chem Impex
Product Number
08219
CAS
42856-71-3
Certificate of Analysis (COA)​
COA not found

General Information

PubChem CID
6993664
IUPAC Name
(2S)-2-methylpyrrolidine-2-carboxylic acid
InChI Key
LWHHAVWYGIBIEU-LURJTMIESA-N
SMILES
CC@1(CCCN1)C(=O)O

Application

L-a-Methylproline is widely utilized in research focused on:

Pharmaceutical Development: This compound serves as a building block in the synthesis of various pharmaceuticals, particularly in the development of peptide-based drugs. Its unique structure can enhance the stability and bioavailability of drug candidates.

Protein Engineering: In biochemistry, L-a-Methylproline is used to modify peptide sequences, allowing researchers to study the effects of structural changes on protein function and stability, which is crucial for drug design.

Material Science: This chemical is explored in the creation of new materials, particularly in polymers where its incorporation can improve mechanical properties and thermal stability, making it valuable for advanced manufacturing.

Cosmetic Formulations: With its potential skin benefits, L-a-Methylproline is being researched for use in cosmetic products, where it may enhance skin hydration and elasticity, appealing to the beauty industry.

Amino Acid Research: As a non-standard amino acid, it provides insights into protein folding and function, helping researchers understand diseases related to protein misfolding, which is vital in fields like neurobiology.

References Data Source From Pubchem

Trofinetide

Publication Name: Pharmaceutical Substances
Publication Date: 2025

Rett syndrome

Publication Name: Nature reviews. Disease primers
Publication Date: 2024-11-07
DOI: 10.1038/s41572-024-00568-0|10.1038/s41572-024-00576-0

Characterization of the Pharmacokinetics and Mass Balance of a Single Oral Dose of Trofinetide in Healthy Male Subjects

Publication Name: Clinical Drug Investigation
Publication Date: 2023-11-28
DOI: 10.1007/s40261-023-01322-2

1,3-Elimination of HBr from dimethyl (2S,4RS)-4-bromo-N-phthaloylglutamate under the action of bases: a theoretical study

Publication Name: Russian Chemical Bulletin
Publication Date: 2023-09
DOI: 10.1007/s11172-023-3992-x