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Product Information

Product Name
Fmoc-L-proline pentafluorophenyl ester
Brand Name
Chem Impex
Product Number
02449
CAS
86060-90-4
Certificate of Analysis (COA)​
COA not found

General Information

PubChem CID
2733412
IUPAC Name
1-O-(9H-fluoren-9-ylmethyl) 2-O-(2,3,4,5,6-pentafluorophenyl) (2S)-pyrrolidine-1,2-dicarboxylate
InChI Key
CQBLOHXKGUNWRV-SFHVURJKSA-N
SMILES
C1CC@H(N(C1)C(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24)C(=O)OC5=C(C(=C(C(=C5F)F)F)F)F

Application

Fmoc-L-proline pentafluorophenyl ester is widely utilized in research focused on:

Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, allowing for the introduction of proline residues with high efficiency and specificity.

Drug Development: It is used in the design of pharmaceutical compounds, particularly in creating peptide-based drugs that target specific biological pathways, enhancing therapeutic efficacy.

Bioconjugation: The ester can be employed in bioconjugation techniques, linking biomolecules to surfaces or other molecules, which is crucial in developing biosensors and drug delivery systems.

Research in Protein Engineering: It aids researchers in modifying proteins to study structure-function relationships, providing insights into protein behavior and interactions.

Fluorinated Compound Applications: The presence of fluorine enhances the stability and bioavailability of compounds, making it valuable in various applications in medicinal chemistry.

References Data Source From Pubchem

Effect of core epitope modification on the antibody recognition of a MUC2 mucin peptide

Publication Name: Molecular Diversity
Publication Date: 2012-02
DOI: 10.1007/s11030-012-9362-5

Antibody Epitope Mapping Using Arrays of Synthetic Peptides

Publication Name: Antibody Engineering
Publication Date: 2003-12-05
DOI: 10.1385/1-59259-666-5:443

Convenient and simple homologation ofNα-urethane protected α-amino acids to their β-homologues with concomitant pentafluorophenyl ester formation

Publication Name: International Journal of Peptide Research and Therapeutics
Publication Date: 2000-05
DOI: 10.1007/bf02443584|10.1023/a:1008934125453

Intramolecular Fluorescence-Quenched Substrate Libraries

Publication Name: Combinatorial Peptide Library Protocols
Publication Date: 1997-12-23
DOI: 10.1385/0-89603-392-9:65