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Product Information

Product Name
Fmoc-L-proline
Brand Name
Chem Impex
Product Number
02448
CAS
71989-31-6
Certificate of Analysis (COA)​
COA not found

General Information

PubChem CID
688135
IUPAC Name
(2S)-1-(9H-fluoren-9-ylmethoxycarbonyl)pyrrolidine-2-carboxylic acid
InChI Key
ZPGDWQNBZYOZTI-SFHVURJKSA-N
SMILES
C1CC@H(N(C1)C(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24)C(=O)O

Application

Fmoc-L-proline is widely utilized in research focused on:

Peptide Synthesis: This compound serves as a protective group in solid-phase peptide synthesis, allowing for the selective formation of peptide bonds while preventing unwanted reactions. Its stability under various conditions makes it a preferred choice for chemists.

Drug Development: In pharmaceutical research, Fmoc-L-proline is used to create peptide-based drugs. Its ability to enhance the stability and bioavailability of therapeutic peptides is crucial in developing effective medications.

Bioconjugation: The compound is employed in bioconjugation processes to attach biomolecules to surfaces or other molecules. This application is vital in creating targeted drug delivery systems and diagnostic tools.

Protein Engineering: Researchers utilize Fmoc-L-proline in the design of modified proteins. Its unique structure allows for the incorporation of proline residues, which can influence protein folding and stability, leading to improved functionality.

Material Science: In the development of new materials, Fmoc-L-proline is used to create polymeric systems with specific properties. Its role in enhancing the mechanical and thermal properties of materials is beneficial in various industrial applications.

References Data Source From Pubchem

Water-based coupling of amino acids for sustainable solid-phase peptide synthesis

Publication Name: Nature Sustainability
Publication Date: 2026-02-03
DOI: 10.1038/s41893-025-01761-z

Potential Enhancement of Topical Drug Delivery Using Grapefruit-derived Nanoparticles Modified Using TAT Peptide

Publication Name: Pharmaceutical Research
Publication Date: 2026-01-21
DOI: 10.1007/s11095-026-04014-6

Identification of an αvβ3-targeting bicyclic peptide with atypical norArg-Gly-Asp sequence

Publication Name: Communications Chemistry
Publication Date: 2026-01-12
DOI: 10.1038/s42004-026-01886-y

Intelligent design and synthesis of nucleobase and amino acid-based ligands to inhibit the JAK2 enzyme to treat rheumatoid arthritis

Publication Name: Amino Acids
Publication Date: 2025-11-07
DOI: 10.1007/s00726-025-03487-w

Enhanced atherosclerosis molecular imaging and therapy with collagen hybridizing peptide functionalized albumin nanoparticles

Publication Name: Journal of Nanobiotechnology
Publication Date: 2025-10-28
DOI: 10.1186/s12951-025-03721-3