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Chem Impex
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Product Information

Product Name
Fmoc-O-tert-butyl-L-trans-4-hydroxyproline
Brand Name
Chem Impex
Product Number
02424
CAS
122996-47-8
Certificate of Analysis (COA)​
COA not found

General Information

PubChem CID
978347
IUPAC Name
(2S,4R)-1-(9H-fluoren-9-ylmethoxycarbonyl)-4-(2-methylpropan-2-yl)oxypyrrolidine-2-carboxylic acid
InChI Key
WPBXBYOKQUEIDW-VFNWGFHPSA-N
SMILES
CC(C)(C)OC@@H1CC@H(N(C1)C(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24)C(=O)O

Application

Fmoc-O-tert-butyl-L-trans-4-hydroxyproline is widely utilized in research focused on:

Peptide Synthesis: This compound is commonly used as a building block in the synthesis of peptides, particularly in solid-phase peptide synthesis, due to its stability and ease of removal during deprotection steps.

Drug Development: It plays a crucial role in the development of pharmaceuticals, especially in creating compounds that target specific biological pathways, enhancing the efficacy of drug candidates.

Bioconjugation: The chemical is valuable in bioconjugation processes, allowing researchers to attach biomolecules to surfaces or other molecules, which is essential for creating targeted therapies and diagnostics.

Protein Engineering: In protein engineering, it helps in modifying proteins to improve their stability and functionality, making it easier to design proteins with desired characteristics for industrial applications.

Research in Structural Biology: It is utilized in the study of protein structures, aiding in the understanding of protein folding and interactions, which is vital for advancing knowledge in biochemistry and molecular biology.

References Data Source From Pubchem

Enhanced atherosclerosis molecular imaging and therapy with collagen hybridizing peptide functionalized albumin nanoparticles

Publication Name: Journal of Nanobiotechnology
Publication Date: 2025-10-28
DOI: 10.1186/s12951-025-03721-3

Design, Synthesis, and Application of OB2C Combinatorial Peptide and Peptidomimetic Libraries

Publication Name: Methods in molecular biology (Clifton, N.J.)
Publication Date: 2015
DOI: 10.1007/978-1-4939-2020-4_1

Peptide Optimization and Conjugation Strategies in the Development of Molecularly Targeted Magnetic Resonance Imaging Contrast Agents

Publication Name: Methods in molecular biology (Clifton, N.J.)
Publication Date: 2014
DOI: 10.1007/978-1-62703-673-3_13

Structure–Activity Studies of Phosphopeptidomimetic Prodrugs Targeting the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 3 (Stat3)

Publication Name: International Journal of Peptide Research and Therapeutics
Publication Date: 2012-07-08
DOI: 10.1007/s10989-012-9313-0