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Sku CI02423_5_G
Chem Impex
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Product Information

Product Name
Fmoc-L-trans-4-hydroxyproline
Brand Name
Chem Impex
Product Number
02423
CAS
88050-17-3
Certificate of Analysis (COA)​
COA not found

General Information

PubChem CID
2756109
IUPAC Name
(2S,4R)-1-(9H-fluoren-9-ylmethoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid
InChI Key
GOUUPUICWUFXPM-XIKOKIGWSA-N
SMILES
C1C@H(CN(C@@H1C(=O)O)C(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24)O

Application

Fmoc-L-trans-4-hydroxyproline is widely utilized in research focused on:

Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, particularly in the creation of modified peptides that require specific stereochemistry for biological activity.

Drug Development: It is used in the pharmaceutical industry to develop new drugs, especially those targeting collagen-related diseases, due to its structural similarity to proline.

Biomaterials: In tissue engineering, it is incorporated into hydrogels and scaffolds, enhancing the mechanical properties and biocompatibility of materials used for cell growth and regeneration.

Research on Protein Folding: This compound aids researchers in studying protein folding and stability, providing insights into how modifications can affect protein behavior.

Cosmetic Formulations: It is also found in cosmetic products aimed at improving skin elasticity and hydration, leveraging its properties to enhance formulations.

References Data Source From Pubchem

Tissue and plasma free amino acid detection by LC-MS/MS method in high grade glioma patients

Publication Name: Journal of Neuro-Oncology
Publication Date: 2023-06
DOI: 10.1007/s11060-023-04329-z

Programmable Fabrication of Multilayer Collagen Nanosheets of Defined Composition

Publication Name: Methods in Molecular Biology
Publication Date: 2018
DOI: 10.1007/978-1-4939-7811-3_13

Antioxidant activity of caffeoyl-prolyl-histidine amide and its effects on PDGF-induced proliferation of vascular smooth muscle cells

Publication Name: Amino Acids
Publication Date: 2014-09-14
DOI: 10.1007/s00726-014-1834-8

Aggregation modes of the spin mono-labeled tylopeptin B and heptaibin peptaibiotics in frozen solutions of weak polarity as studied by PELDOR spectroscopy

Publication Name: Journal of Structural Chemistry
Publication Date: 2013-09
DOI: 10.1134/s0022476613070056

Optimization of Physicochemical and Pharmacological Properties of Peptide Drugs by Glycosylation

Publication Name: Peptide Modifications to Increase Metabolic Stability and Activity
Publication Date: 2013
DOI: 10.1007/978-1-62703-652-8_8