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Product Information

Product Name
Fmoc-D-proline
Brand Name
Chem Impex
Product Number
02064
CAS
101555-62-8
Certificate of Analysis (COA)​
COA not found

General Information

PubChem CID
688136
IUPAC Name
(2R)-1-(9H-fluoren-9-ylmethoxycarbonyl)pyrrolidine-2-carboxylic acid
InChI Key
ZPGDWQNBZYOZTI-GOSISDBHSA-N
SMILES
C1CC@@H(N(C1)C(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24)C(=O)O

Application

Fmoc-D-proline is widely utilized in research focused on:

Peptide Synthesis: It serves as a key building block in the synthesis of peptides, particularly in solid-phase peptide synthesis (SPPS), allowing for the incorporation of proline residues with high efficiency.

Drug Development: Researchers use it to develop novel therapeutic peptides, enhancing the stability and bioavailability of drug candidates, which is crucial in pharmaceutical formulations.

Bioconjugation: Fmoc-D-proline is employed in bioconjugation strategies, facilitating the attachment of biomolecules to surfaces or other molecules, which is important in creating targeted drug delivery systems.

Protein Engineering: It is utilized in the design of modified proteins with specific functionalities, aiding in the development of enzymes or antibodies with enhanced properties for industrial and medical applications.

Research in Structural Biology: The compound plays a significant role in studying protein folding and stability, providing insights that are essential for understanding various biological processes.

References Data Source From Pubchem

Rapid clearance of achiral small-molecule drugs using de novo-designed proteins and their cyclic and mirror-image variants

Publication Name: Nature Biomedical Engineering
Publication Date: 2025-05-29
DOI: 10.1038/s41551-025-01404-w

Accurate de novo design of heterochiral protein–protein interactions

Publication Name: Cell Research
Publication Date: 2024-08-14
DOI: 10.1038/s41422-024-01014-2

Covalent Reactive Peptides to Block Protein–Protein Interactions and Inhibit Microbe–Host Interaction

Publication Name: Methods in molecular biology (Clifton, N.J.)
Publication Date: 2022-06-28
DOI: 10.1007/978-1-0716-2489-0_5

Rapid de novo discovery of peptidomimetic affinity reagents for human angiotensin converting enzyme 2

Publication Name: Communications Chemistry
Publication Date: 2022-01-19
DOI: 10.1038/s42004-022-00625-3

Peptide Synthesis: Methods and Protocols

Publication Name: AAPS Advances in the Pharmaceutical Sciences Series
Publication Date: 2022
DOI: 10.1007/978-3-031-04544-8_2