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Product Information

Product Name
Fmoc-4-chloro-L-phenylalanine
Brand Name
Chem Impex
Product Number
02568
CAS
175453-08-4
Certificate of Analysis (COA)​
COA not found

General Information

PubChem CID
2734471
IUPAC Name
(2S)-3-(4-chlorophenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid
InChI Key
CQPNKLNINBUUOM-QFIPXVFZSA-N
SMILES
C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)NC@@H(CC4=CC=C(C=C4)Cl)C(=O)O

Application

Fmoc-4-chloro-L-phenylalanine is widely utilized in research focused on

Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, particularly in solid-phase peptide synthesis (SPPS), allowing researchers to create complex peptide sequences efficiently.

Drug Development: Its unique structure makes it valuable in the pharmaceutical industry for developing new drugs, especially those targeting specific receptors or enzymes, enhancing therapeutic efficacy.

Bioconjugation: The compound is used in bioconjugation processes, where it helps link biomolecules to other entities, such as drugs or imaging agents, improving drug delivery systems.

Research in Protein Engineering: It plays a significant role in protein engineering, allowing scientists to modify proteins for better stability or activity, which is crucial in biotechnology applications.

Fluorescent Labeling: Fmoc-4-chloro-L-phenylalanine can be used in fluorescent labeling techniques, aiding in the visualization of proteins and peptides in various biological studies.

References Data Source From Pubchem

Pyridyl-Ala in the third position of radiolabeled somatostatin antagonists: the effect of regioisomeric substitution

Publication Name: EJNMMI Radiopharmacy and Chemistry
Publication Date: 2025-07-01
DOI: 10.1186/s41181-025-00363-6

Halogen bonding modulates hydrogel formation from Fmoc amino acids

Publication Name: CrystEngComm
Publication Date: 2017
DOI: 10.1039/c7ce00031f