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Product Information

Product Name
Fmoc-D-phenylalanine
Brand Name
Chem Impex
Product Number
02444
CAS
86123-10-6
Certificate of Analysis (COA)​
COA not found

General Information

PubChem CID
978332
IUPAC Name
(2R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-phenylpropanoic acid
InChI Key
SJVFAHZPLIXNDH-JOCHJYFZSA-N
SMILES
C1=CC=C(C=C1)CC@H(C(=O)O)NC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24

Application

Fmoc-D-phenylalanine is widely utilized in research focused on:

Peptide Synthesis: This compound serves as a protective group in solid-phase peptide synthesis, allowing for the selective modification of amino acids during the formation of peptides.

Drug Development: It is used in the design of peptide-based drugs, enhancing the stability and bioavailability of therapeutic agents in pharmaceutical formulations.

Biotechnology: Researchers employ it in the creation of peptide libraries for screening potential drug candidates, facilitating the discovery of new therapeutic compounds.

Protein Engineering: Fmoc-D-phenylalanine is instrumental in modifying proteins to improve their function or stability, which is crucial in developing biocatalysts and enzymes.

Research in Neuroscience: This compound is utilized in studies related to neurotransmitter pathways, helping to understand the role of peptides in brain function and behavior.

References Data Source From Pubchem

Rapid clearance of achiral small-molecule drugs using de novo-designed proteins and their cyclic and mirror-image variants

Publication Name: Nature Biomedical Engineering
Publication Date: 2025-05-29
DOI: 10.1038/s41551-025-01404-w

Diol as a New Pantetheine Surrogate for Chemoenzymatic Synthesis of Cyclic Peptides via Nonribosomal Peptide Cyclases

Publication Name: Methods in molecular biology (Clifton, N.J.)
Publication Date: 2025
DOI: 10.1007/978-1-0716-4562-8_10

Synthesis of Polymyxin-Inspired Peptidomimetics

Publication Name: Methods in molecular biology (Clifton, N.J.)
Publication Date: 2025
DOI: 10.1007/978-1-0716-4562-8_22

Accurate de novo design of heterochiral protein–protein interactions

Publication Name: Cell Research
Publication Date: 2024-08-14
DOI: 10.1038/s41422-024-01014-2

Repurposing a plant peptide cyclase for targeted lysine acylation

Publication Name: Nature Chemistry
Publication Date: 2024-05-24
DOI: 10.1038/s41557-024-01520-1