Lapatinib Impurity 14|C4X-119114|697299-82-4

Lapatinib Impurity 14

Cat. No S57C4X-119114_5_MG

Vendor: US-CATO

Product Information

Product Name

Lapatinib Impurity 14

Brand Name

US-CATO

Product Number

C4X-119114

CAS

697299-82-4

Certificate of Analysis (COA)

COA not found

General Information

PubChem CID

21952026

IUPAC Name

6-5-(aminomethyl)furan-2-yl-N-3-chloro-4-(3-fluorophenyl)methoxyphenylquinazolin-4-amine

InChI Key

NQHFMDSFFGTFSK-UHFFFAOYSA-N

SMILES

C1=CC(=CC(=C1)F)COC2=C(C=C(C=C2)NC3=NC=NC4=C3C=C(C=C4)C5=CC=C(O5)CN)Cl

References Data Source From Pubchem

Studies on the Role of Metabolic Activation in Tyrosine Kinase Inhibitor–Dependent Hepatotoxicity: Induction of CYP3A4 Enhances the Cytotoxicity of Lapatinib in HepaRG Cells

Publication Name: Drug metabolism and disposition: the biological fate of chemicals

Publication Date: 2014-01

DOI: 10.1124/dmd.113.054817

Metabolism-Dependent Inhibition of CYP3A4 by Lapatinib: Evidence for Formation of a Metabolic Intermediate Complex with a Nitroso/Oxime Metabolite Formed via a Nitrone Intermediate

Publication Name: Drug metabolism and disposition: the biological fate of chemicals

Publication Date: 2013-05

DOI: 10.1124/dmd.113.051151

Interaction of Lapatinib with Cytochrome P450 3A5

Publication Name: Drug metabolism and disposition: the biological fate of chemicals

Publication Date: 2012-07

DOI: 10.1124/dmd.112.044958

Human Metabolism of Lapatinib, a Dual Kinase Inhibitor: Implications for Hepatotoxicity

Publication Name: Drug metabolism and disposition: the biological fate of chemicals

Publication Date: 2012-01

DOI: 10.1124/dmd.111.040949

Metabolic Intermediate Complex Formation of Human Cytochrome P450 3A4 by Lapatinib

Publication Name: Drug metabolism and disposition: the biological fate of chemicals

Publication Date: 2011-06

DOI: 10.1124/dmd.110.037531