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Chem Impex
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Product Information

Product Name
Fmoc-N-methyl-L-isoleucine
Brand Name
Chem Impex
Product Number
02657
CAS
138775-22-1
Certificate of Analysis (COA)​
COA not found

General Information

PubChem CID
15433034
IUPAC Name
(2S,3S)-2-9H-fluoren-9-ylmethoxycarbonyl(methyl)amino-3-methylpentanoic acid
InChI Key
IQIOLCJHRZWOLS-XOBRGWDASA-N
SMILES
CCC@H(C)C@@H(C(=O)O)N(C)C(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13

Application

Fmoc-N-methyl-L-isoleucine is widely utilized in research focused on:

Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, particularly in solid-phase peptide synthesis. Its Fmoc protecting group allows for easy removal during the synthesis process, making it a preferred choice for researchers.

Drug Development: In pharmaceutical research, it is used to create peptide-based drugs. Its unique structure can enhance the bioactivity of peptides, leading to more effective therapeutic agents.

Bioconjugation: The compound is employed in bioconjugation techniques, where it helps link peptides to other biomolecules, such as antibodies or enzymes, facilitating targeted drug delivery systems.

Protein Engineering: Researchers utilize this compound to modify proteins, improving their stability and functionality. This is particularly beneficial in developing enzymes with enhanced catalytic properties.

Analytical Chemistry: It is also used in analytical methods to study protein interactions and conformational changes, providing insights into protein behavior in various environments.

References Data Source From Pubchem

Discovery of a nitroaromatic nannocystin with potent in vivo anticancer activity against colorectal cancer by targeting AKT1

Publication Name: Acta Pharmacologica Sinica
Publication Date: 2024-02-07
DOI: 10.1038/s41401-024-01231-w

The Chemical Syntheses of Nannocystins

Publication Name: Synthesis
Publication Date: 2019-04-17
DOI: 10.1055/s-0037-1611796