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Sku CI03987_1_G
Chem Impex
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Product Information

Product Name
Na-Boc-L-histidine methyl ester
Brand Name
Chem Impex
Product Number
03987
CAS
2488-14-4
Certificate of Analysis (COA)​
COA not found

General Information

PubChem CID
7017200
IUPAC Name
methyl (2S)-3-(1H-imidazol-5-yl)-2-(2-methylpropan-2-yl)oxycarbonylaminopropanoate
InChI Key
RWEVEEORUORBAX-VIFPVBQESA-N
SMILES
CC(C)(C)OC(=O)NC@@H(CC1=CN=CN1)C(=O)OC

Description

Na-Boc-L-histidine methyl ester is widely utilized in research focused on:

Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, particularly those that require histidine residues, enhancing the efficiency of creating complex biomolecules.

Drug Development: It plays a significant role in the design of pharmaceuticals, especially in developing histidine-containing drugs, which can improve solubility and bioavailability.

Bioconjugation: The compound is used in bioconjugation processes, allowing researchers to attach biomolecules to surfaces or other molecules, which is crucial in creating targeted therapies and diagnostics.

Protein Engineering: It aids in the modification of proteins to study their functions and interactions, providing insights that are vital for advancements in biotechnology and therapeutic applications.

Research on Enzyme Activity: This chemical is utilized in studies examining enzyme activity, particularly those involving histidine residues, helping to elucidate mechanisms of action and potential inhibitors.

References Data Source From Pubchem

Directed synthesis of N1/N3-histidine modified by 2-hydroxyethylthioethyl and identification in sulfur mustard-exposed plasma

Publication Name: Communications Chemistry
Publication Date: 2025-03-08
DOI: 10.1038/s42004-025-01479-1

An Atom-Efficient Direct Regioselective N(τ)-Allylation of Histidine Deriva­tives

Publication Name: Synlett
Publication Date: 2012-11-19
DOI: 10.1055/s-0032-1317669

Synthesis of a Novel γ-Folic Acid-N τ-Histidine Conjugate Suitable for Labeling with 99mTc and 188Re

Publication Name: Synthesis
Publication Date: 2009-01-27
DOI: 10.1055/s-0028-1083345

Basic Side-Chain Protection

Publication Name: Science of Synthesis
Publication Date: 2005