Bis(1,5-cyclooctadiene)nickel (0), 98+%

Technical Notes：
1.Pre catalyst for the coupling of benzoxazole with N-tosylhydrazone.
2.Catalyst precursor for heterogeneously nickel-catalysed hydrogenolysis of aryl ethers without
arene hydrogenation.
3.Pre-catalyst for reductive cleavage of C-OMe bonds with silanes as reducing agents .
4.Pre-catalyst for the cross-coupling reactions of benzylic pivalates with arylboroxines.
5.Pre-catalyst for the cross-coupling of benzylic carbamates with arylboronic esters.
6.Pre catalyst for the direct arylation of C(sp')-H Bonds in aliphatic amides via bidentate- chelation.
7.Pre -catalyst for the cross-coupling reactions of potassium alkoxyalkyl- and benzyltrifluoroborates with an array of aryl bromides and co-catalyzed by iridium photoredox catalyst under visible light at ambienttemperature.
8.Pre-catalyst for highly regioselective indoline synthesis, co-catalyzed by Iridium photoredox catalyst. 9. Catalyst for conversion of amides to esters via the activation of amide C-N bonds.
10. Catalyst for borylation of aryl fluorides via C-F cleavage .
11. Catalyst for Suzuki-Miyaura coupling of amides .
12. Catalyst for the cross-coupling reaction of the aryl methyl ether alkylation.

1. What is Ni(COD)₂?

Ni(COD)₂ is the common abbreviation for Bis(1,5-cyclooctadiene)nickel(0), a zero-valent nickel complex used primarily as a precursor for nickel-based catalysts.

2. What is the CAS number of Ni(COD)₂?

Its CAS number is 1295-35-8.

3. What is the molecular formula of Ni(COD)₂?

The molecular formula is C₁₆H₂₄Ni.

4. What is the molecular weight of Ni(COD)₂?

Its molecular weight is approximately 275.06 g/mol.

5. What is the oxidation state of nickel in Ni(COD)₂?

Nickel is formally in the zero oxidation state (Ni(0)).

6. What is the primary use of Ni(COD)₂ in organic synthesis?

It is primarily used as a nickel precursor for preparing homogeneous catalysts and investigating nickel-catalyzed organic transformations.

7. Why are the COD ligands important?

The COD ligands stabilize the nickel center while remaining sufficiently labile to be displaced by other coordinating ligands during catalyst preparation.

8. Is Ni(COD)₂ sensitive to air and moisture?

Yes. It is sensitive to air, moisture, and light, so inert-atmosphere handling and appropriate storage are recommended.

9. How should Ni(COD)₂ be stored?

Follow the supplier's instructions. Some commercial specifications recommend storage under inert gas at −20°C, protected from light and moisture.

10. What safety precautions are required when handling Ni(COD)₂?

It should be handled by trained laboratory personnel using suitable containment, ventilation, and protective equipment. Review the current SDS because the compound presents flammability and significant health hazards.