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Sku CI02571_1_G
Chem Impex
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Product Information

Product Name
3-Fluoro-L-phenylalanine
Brand Name
Chem Impex
Product Number
02571
CAS
19883-77-3
Certificate of Analysis (COA)​
COA not found

General Information

PubChem CID
716315
IUPAC Name
(2S)-2-amino-3-(3-fluorophenyl)propanoic acid
InChI Key
VWHRYODZTDMVSS-QMMMGPOBSA-N
SMILES
C1=CC(=CC(=C1)F)CC@@H(C(=O)O)N

Application

3-Fluoro-L-phenylalanine is widely utilized in research focused on:

Drug Development: This compound serves as a valuable building block in the synthesis of novel pharmaceuticals, particularly in the development of targeted therapies for cancer and neurological disorders.

Protein Engineering: It is employed in the modification of proteins to study structure-function relationships, enabling researchers to create proteins with enhanced stability or altered activity.

Biochemical Research: The compound is used in studies investigating metabolic pathways and enzyme mechanisms, providing insights into biochemical processes that could lead to new therapeutic strategies.

Fluorinated Amino Acids: Its unique fluorine atom allows for improved imaging techniques in molecular biology, aiding in the visualization of protein interactions and cellular processes.

Pharmaceutical Formulations: As a chiral building block, it plays a role in the formulation of drugs that require specific stereochemistry, enhancing efficacy and reducing side effects compared to non-fluorinated counterparts.

References

A new preparation process to afuresertib, a pan-AKT inhibitor under clinical development

Publication Name: Chemical Papers
Publication Date: 2025-04-09
DOI: 10.1007/s11696-025-03989-7

Engineering yeast metabolism for the discovery and production of polyamines and polyamine analogues

Publication Name: Nature Catalysis
Publication Date: 2021-06-17
DOI: 10.1038/s41929-021-00631-z

Expanding the enzyme universe with genetically encoded unnatural amino acids

Publication Name: Nature Catalysis
Publication Date: 2020-01-06
DOI: 10.1038/s41929-019-0410-8

Approaches to α-Amino Acids Based on Deracemization and Stereoinversion

Publication Name: Science of Synthesis
Publication Date: 2019

LAT-1 activity of meta-substituted phenylalanine and tyrosine analogs

Publication Name: Bioorganic & Medicinal Chemistry Letters
Publication Date: 2016-06-01
DOI: 10.1016/j.bmcl.2016.04.023