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Sku CI29925_5_G
Chem Impex
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Product Information

Product Name
Hygromycin B from Streptomyces hygroscopicus
Brand Name
Chem Impex
Product Number
29925
CAS
31282-04-9
Certificate of Analysis (COA)​
COA not found

General Information

PubChem CID
56928061
IUPAC Name
(3'R,3aS,4S,4'S,5'R,6R,6'R,7S,7aS)-4-(1R,2S,3R,5S,6R)-3-amino-2,6-dihydroxy-5-(methylamino)cyclohexyloxy-6'-(1S)-1-amino-2-hydroxyethyl-6-(hydroxymethyl)spiro4,6,7,7a-tetrahydro-3aH-1,3dioxolo4,5-cpyran-2,2'-oxane-3',4',5',7-tetrol
InChI Key
GRRNUXAQVGOGFE-HUCHGKBZSA-N
SMILES
CNC@H1CC@H(C@@H(C@H(C@@H1O)OC@H2C@@H3C@H(C@H(C@H(O2)CO)O)OC4(O3)C@@H(C@H(C@H(C@H(O4)C@H(CO)N)O)O)O)O)N

Description

Hygromycin B from Streptomyces hygroscopicus is widely utilized in research focused on:

Antibiotic Research: It serves as a potent antibiotic, particularly in studies investigating bacterial resistance mechanisms and the development of new antimicrobial agents.

Gene Selection: Commonly used in molecular biology, it acts as a selective agent for transgenic cells, helping researchers identify successfully modified organisms in plant and animal studies.

Cell Culture Applications: In cell culture, it is employed to maintain the integrity of genetically modified cell lines, ensuring that only those expressing the desired traits survive.

Veterinary Medicine: Hygromycin B is utilized in veterinary applications to treat infections in livestock, providing a reliable option for managing bacterial diseases.

Biotechnology: It plays a crucial role in the production of recombinant proteins, aiding in the selection of high-yielding cell lines for biopharmaceutical manufacturing.

References Data Source From Pubchem

Structural and molecular basis of specialized translation mediated by the ribosome mRNA-binding channel

Publication Name: Nature Communications
Publication Date: 2026-04-29
DOI: 10.1038/s41467-026-72263-5

N1-Methylpseudouridine directly modulates translation dynamics

Publication Name: Nature
Publication Date: 2026-01-14
DOI: 10.1038/s41586-025-09945-5

Hygromycin A Treatment of Borrelia burgdorferi –Infected Peromyscus leucopus Suggests Potential as a Reservoir-Targeted Antibiotic

Publication Name: The Journal of Infectious Diseases
Publication Date: 2025-07-04
DOI: 10.1093/infdis/jiaf363

Deciphering hygromycin B biosynthetic pathway and D-optimal design for production optimization

Publication Name: World Journal of Microbiology and Biotechnology
Publication Date: 2025-04-28
DOI: 10.1007/s11274-025-04364-0

Structural basis for hygromycin B inhibition of yeast pseudouridine-deficient ribosomes

Publication Name: Science Advances
Publication Date: 2025-04-04
DOI: 10.1126/sciadv.adu0151