Fluorine is an important non-metal element. Due to its unique electronegativity, electronic effect and steric hindrance effect, fluorine atoms are often introduced into drugs to regulate drug metabolism pathways, improve metabolic stability and permeability, etc., and have been More than 20% of drugs and pesticides on the market contain one or more fluorine atoms. The green and efficient synthesis of fluoride has become a research hotspot in fluorine chemistry. Shen Qilong’s team at the Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, has developed two new types of trifluoromethylthiolation reagents—N-trifluoromethylthiosaccharin and trifluoromethyloxysulfide, which have good stability and a wide substrate range. , the reaction speed is fast, the conditions are mild, and the yield is high. Compared with the commonly used gaseous trifluoromethyl sulfide reagent trifluoromethyl sulfoxide chloride, the operation is simple and safe.

J&K Scientific can provide a variety of reagents required for the synthesis and transformation methodology of fluorine-containing compounds:

Full range: covering fluorinated reagents, fluorinated building blocks, catalysts and ligands, alkynes, boron-containing compounds, organometallic reagents, synthetic reagents, etc. We also provide supporting inorganic reagents, ultra-dry solvents, nuclear magnetic solvents and common instrument consumables. ;
New products: new fluorinated reagents that can be used to transform the scientific research results of scientists in this field;
Quality assurance: high purity, strict quality control, and stable batch quality.

Recommended products

Fluorine building blocks

Catalysts and ligands

Photocatalyst

Alkynes

Boron compounds

Organometallic reagents

Synthetic reagents

General product