Synthetic polypeptides (polyamino acids, poly-α-glutamic acid) have emerged as a class of biomedical materials widely applied in drug delivery systems, tissue engineering scaffolds, antimicrobial agents, and as alternatives to polyethylene glycol (PEG).

Polypeptides are typically synthesized via ring-opening polymerization (ROP) of amino acid N-carboxyanhydride (NCA) monomers. However, their broader application has been hindered by challenges in synthesis and difficulties in controlling production costs.

Professor Hua Lv's research group is dedicated to the fundamental and applied studies of NCA ring-opening polymerization and amino acid-based biomedical polymeric materials. In their previous work, leveraging epoxy scavengers, they developed a novel method for preparing unprotected NCA monomers under ambient conditions—in the presence of moisture and oxygen—enabling robust, large-scale production of NCA monomers. They also discovered that water can act as a proton shuttle to significantly accelerate the ring-opening polymerization of proline NCA. Building on these findings, the group further introduced carboxylic acids as proton transfer catalysts to achieve rapid and controllable polymerization of sarcosine NCA (Sar-NCA), thereby enabling the synthesis of ultra-high molecular weight polysarcosine (pSar). These discoveries have laid a methodological and material foundation for the broader application of polypeptides and deepened the scientific understanding of the NCA ring-opening polymerization mechanism.

Prof. Hua Lv obtained his BSc from Peking University (2002-2006) and PhD from University of Illinois at Urbana-Champaign (2006-2011).
He conducted postdoctoral research in the Department of Chemistry at the internationally renowned Scripps Research Institute from 2011 to 2014. Since 2014, Professor Hua Lv has returned to Peking University, where he serves as a faculty member in the College of Chemistry and Molecular Engineering, dedicating his efforts to pioneering research in polymer chemistry and biomedical materials.
His research is primarily dedicated to polymer chemistry, degradable biomedical polymer materials, and biopharmaceutical engineering, with a focus on the controlled construction of amino acid-based degradable polymers and their efficient protein conjugation. This involves designing and synthesizing novel amino acid-based monomers and degradable polymers, developing polymerization initiators, and achieving precise synthesis of protein-degradable polymer conjugates to explore their structure-activity relationships and applications.

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Related Product

• #Cat9420730 Poly-α-glutamic acid, 98%, PDI<1.3, average Mn: 7.97k

Product Advantages

• Narrow Dispersity: PDI < 1.3, molecular weight range 2k – 10k, offering enhanced advantages in biodegradability and transdermal absorption.
• High Purity: Purity ≥ 98%.
• Excellent Safety Profile: Poly-α-glutamic acid is chemically synthesized, ensuring high product uniformity, no endotoxin introduction, and superior safety. Its natural peptide bonds facilitate easy degradation by endogenous enzymes.
• Customization Capability: High end-group fidelity allows for tailored customization of various end groups.

• Kilogram-Scale Supply: Equipped with specialized production and scale-up facilities as well as personnel, enabling kilogram-scale manufacturing.