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Available on backorder. Please allow 2-3 weeks for production.
Sku CI07038_250_MG
Chem Impex
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Product Information

Product Name
6-Diazo-5-oxo-L-norleucine
Brand Name
Chem Impex
Product Number
07038
CAS
157-03-9
Certificate of Analysis (COA)​
COA not found

General Information

PubChem CID
9087
IUPAC Name
(2S)-2-amino-6-diazo-5-oxohexanoic acid
InChI Key
YCWQAMGASJSUIP-YFKPBYRVSA-N
SMILES
C(CC(=O)C=N+=N-)C@@H(C(=O)O)N

Application

6-Diazo-5-oxo-L-norleucine is widely utilized in research focused on:

Enzyme Inhibition Studies: This compound serves as a potent inhibitor of various enzymes, particularly in studies related to amino acid metabolism, allowing researchers to explore metabolic pathways and enzyme functions.

Neuropharmacology: It is used in neuropharmacological research to investigate its effects on neurotransmitter systems, which can lead to potential therapeutic applications in treating neurological disorders.

Biochemical Research: The compound is valuable in biochemical assays to study the effects of amino acid analogs on protein synthesis, helping scientists understand protein interactions and functions.

Drug Development: 6-Diazo-5-oxo-L-norleucine is explored in the development of new pharmaceuticals, particularly those targeting metabolic diseases, due to its unique structural properties that influence biological activity.

Plant Biology: Researchers utilize this compound to study plant growth and development, particularly in understanding how amino acid analogs affect plant metabolism and stress responses.

References

Filamentation of hCTPS1 with CTP

Publication Name: Cell & Bioscience
Publication Date: 2025-07-30
DOI: 10.1186/s13578-025-01450-6

Understanding and overcoming multidrug resistance in cancer

Publication Name: Nature reviews. Clinical oncology
Publication Date: 2025-07-29
DOI: 10.1038/s41571-025-01059-1

Glutaminase as a metabolic target of choice to counter acquired resistance to Palbociclib by colorectal cancer cells

Publication Name: Oncogene
Publication Date: 2025-07-22
DOI: 10.1038/s41388-025-03495-w

mTORC1 senses glutamine and other amino acids through GCN2

Publication Name: The EMBO Journal
Publication Date: 2025-07-21
DOI: 10.1038/s44318-025-00505-1

Recent advances and challenges of cellular immunotherapies in lung cancer treatment

Publication Name: Experimental Hematology & Oncology
Publication Date: 2025-07-07
DOI: 10.1186/s40164-025-00679-8