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Chem Impex
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Product Information

Product Name
p-Trifluoromethyl-L-phenylalanine
Brand Name
Chem Impex
Product Number
07388
CAS
114926-38-4
Certificate of Analysis (COA)​
COA not found

General Information

PubChem CID
2761501
IUPAC Name
(2S)-2-amino-3-4-(trifluoromethyl)phenylpropanoic acid
InChI Key
CRFFPDBJLGAGQL-QMMMGPOBSA-N
SMILES
C1=CC(=CC=C1CC@@H(C(=O)O)N)C(F)(F)F

Application

p-Trifluoromethyl-L-phenylalanine is widely utilized in research focused on:

Pharmaceutical Development: This compound serves as a valuable building block in the synthesis of novel pharmaceuticals, particularly in designing drugs that target specific biological pathways.

Biochemical Research: It is used in studies investigating protein interactions and enzyme activities, helping researchers understand complex biological systems.

Material Science: The unique properties of this compound make it useful in developing advanced materials, such as polymers with enhanced thermal and chemical resistance.

Fluorine Chemistry: It plays a crucial role in fluorinated compounds, which are often more stable and lipophilic, making them suitable for various applications in medicinal chemistry.

Analytical Chemistry: p-Trifluoromethyl-L-phenylalanine is utilized as a standard in mass spectrometry, aiding in the accurate identification and quantification of amino acids in complex mixtures.

References Data Source From Pubchem

Quantifying protein-drug lifetimes in human cells by 19F NMR spectroscopy

Publication Name: Journal of Biomolecular NMR
Publication Date: 2025-03-24
DOI: 10.1007/s10858-025-00466-x

Site-specific incorporation of 19F-nuclei at protein C-terminus to probe allosteric conformational transitions of metalloproteins

Publication Name: Communications Biology
Publication Date: 2024-12-03
DOI: 10.1038/s42003-024-07331-x

Directed evolution unlocks oxygen reactivity for a nicotine-degrading flavoenzyme

Publication Name: Nature Chemical Biology
Publication Date: 2023-09-28
DOI: 10.1038/s41589-023-01426-y

Structural insights into MIC2 recognition by MIC2-associated protein in Toxoplasma gondii

Publication Name: Communications Biology
Publication Date: 2023-08-31
DOI: 10.1038/s42003-023-05277-0

The ribosome stabilizes partially folded intermediates of a nascent multi-domain protein

Publication Name: Nature Chemistry
Publication Date: 2022-08-04
DOI: 10.1038/s41557-022-01004-0