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Sku CI41756_1_G
Chem Impex
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Product Information

Product Name
Phenylthiohydantoin-isoleucine (contains PTH-alloisoleucine)
Brand Name
Chem Impex
Product Number
41756
CAS
5066-94-4
Certificate of Analysis (COA)​
COA not found

General Information

PubChem CID
3034584
IUPAC Name
5-butan-2-yl-3-phenyl-2-sulfanylideneimidazolidin-4-one
InChI Key
NMRFWXLNHGJLIU-UHFFFAOYSA-N
SMILES
CCC(C)C1C(=O)N(C(=S)N1)C2=CC=CC=C2

Application

Phenylthiohydantoin-isoleucine is widely utilized in research focused on:

Amino Acid Analysis: This compound is essential for identifying and quantifying amino acids in proteins, particularly isoleucine. It helps researchers in biochemistry and molecular biology to analyze protein structures and functions.

Peptide Synthesis: Used in the synthesis of peptides, it aids in creating specific sequences necessary for drug development and therapeutic applications, making it invaluable in pharmaceutical research.

Chiral Resolution: The compound plays a role in separating enantiomers, which is crucial in the production of chiral drugs. This ensures that medications are effective and safe for patients.

Protein Folding Studies: It assists in understanding protein folding mechanisms, which is vital for developing treatments for diseases caused by misfolded proteins, such as Alzheimer’s.

Analytical Chemistry: Employed in chromatographic techniques, it enhances the detection and analysis of complex mixtures, benefiting industries like food safety and environmental monitoring.

References Data Source From Pubchem

Potential of the Flowing Eluent Wall and Aliquot On-Line Detection in the OPLC 50 and 100 Systems

Publication Name: JPC – Journal of Planar Chromatography – Modern TLC
Publication Date: 2008-04
DOI: 10.1556/jpc.21.2008.2.4

Identification of the electrophoretic peaks of the phenylthiohydantoin derivatives of amino acids

Publication Name: Journal of Analytical Chemistry
Publication Date: 2006-01
DOI: 10.1134/s1061934806010035

Identification of PTH-Amino Acids by HPLC

Publication Name: Protein Sequencing Protocols
Publication Date: 2003
DOI: 10.1385/1-59259-342-9:247

Rapid separation of phenylthiohydantoin amino acids: ambient pressure ion-mobility mass spectrometry (IMMS)

Publication Name: Analytical and Bioanalytical Chemistry
Publication Date: 2002-10-31
DOI: 10.1007/s00216-002-1622-2