Afatinib impurity 3|CS-0164261|945553-91-3

Afatinib impurity 3

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Sku TS246CS-0164261_50_MG
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Product Information

Product Name
Afatinib impurity 3
Brand Name
ChemScene
Product Number
CS-0164261
CAS
945553-91-3
Certificate of Analysis (COA)​
COA not found

General Information

PubChem CID
10163178
IUPAC Name
(E)-N-4-(3-chloro-4-fluoroanilino)-7-(3R)-oxolan-3-yloxyquinazolin-6-yl-4-(dimethylamino)but-2-enamide
InChI Key
ULXXDDBFHOBEHA-QDLOVBKTSA-N
SMILES
CN(C)C/C=C/C(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC@@H4CCOC4

References

Design, synthesis, antiproliferative activity and docking studies of quinazoline derivatives bearing 2,3-dihydro-indole or 1,2,3,4-tetrahydroquinoline as potential EGFR inhibitors
Publication Name: European Journal of Medicinal Chemistry
Publication Date: 2018-06-25
DOI: 10.1016/j.ejmech.2018.05.006

How to train your inhibitor: Design strategies to overcome resistance to Epidermal Growth Factor Receptor inhibitors
Publication Name: European Journal of Medicinal Chemistry
Publication Date: 2017-12-15
DOI: 10.1016/j.ejmech.2017.07.023

Structure-based design and synthesis of 2,4-diaminopyrimidines as EGFR L858R/T790M selective inhibitors for NSCLC
Publication Name: European Journal of Medicinal Chemistry
Publication Date: 2017-11-10
DOI: 10.1016/j.ejmech.2017.08.061

Protein Kinase Inhibitor Design by Targeting the Asp-Phe-Gly (DFG) Motif: The Role of the DFG Motif in the Design of Epidermal Growth Factor Receptor Inhibitors
Publication Name: Journal of Medicinal Chemistry
Publication Date: 2013-05-10
DOI: 10.1021/jm400072p