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Ammonium 2-aminoethane-1,1-disulfonic acid, min. 95%
$221.00
Technical Note: 1. This di-sulfonated building block is recommended for post-synthetic water-solubilization of hydrophobic, molecules for applications in biological media, especially organic dyes, fluorophores, azo dyes[1], bodipy[2], coumarin[3] and xanthene dyes[4].This...
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Sku: 02-0570-5G
STREM
Technical Note: 1. This di-sulfonated building block is recommended for post-synthetic water-solubilization of hydrophobic, molecules for applications in biological media, especially organic dyes, fluorophores, azo dyes[1], bodipy[2], coumarin[3] and xanthene dyes[4]. This includes organic supramolecular compounds such as cryptophanes[5], through aminolysis reactions of activated esters, activated carbamates (or carbonates) and isothiocyanates. Such reactions can be performed either in aqueous media (Schotten-Baumann conditions), or in anhydrous organic media (by converting this di-sulfonated taurine analog into the corresponding tributylammonium or tetrabutylammonium salt[2,4]). Such methodology is also applicable for sulfonation of biomolecules such as peptides and nucleic acids, for fine-tuning their net electric charge[6]. A further derivatization of this unusual amine with 3-azidopropanoic acid, 3-mercaptopropanoic acid, or 4-pentynoic acid, provides a di-sulfonated linker that is reactive in either “click” reactions (1,3-dipolar cycloadditions), SNAr or Sonogashira cross-couplings[1]. References: 1. Chem.-Eur., J., 2013, 19, 1686. 2. New J. Chem., 2013, 37, 1016. 3. Dyes Pigm., 2014, 110, 270. 4. Tetrahedron Lett., 2010, 51, 3304. 5. Chem. Commun., 2011, 47, 9702. 6. Bioconjugate Chem., 2014, 25, 1000. |