Ammonium 2-aminoethane-1,1-disulfonic acid, min. 95%

$233.00

FREE
SHIPPING

100% MONEY
BACK GUARANTEE

ONLINE
SUPPORT 24/7

Available on backorder. No lead time available. Please request a quote.
Sku 02-0570-5G
STREM
Technical Note:
 1. This di-sulfonated building block is recommended for post-synthetic water-solubilization of hydrophobic, molecules for applications in biological media, especially organic dyes, fluorophores, azo dyes[1], bodipy[2], coumarin[3] and xanthene dyes[4].
This includes organic supramolecular compounds such as cryptophanes[5], through aminolysis reactions of activated esters, activated carbamates (or carbonates) and isothiocyanates. Such reactions can be performed either in aqueous media
(Schotten-Baumann conditions), or in anhydrous organic media (by converting this di-sulfonated taurine analog into the
corresponding tributylammonium or tetrabutylammonium salt[2,4]). Such methodology is also applicable for sulfonation of
biomolecules such as peptides and nucleic acids, for fine-tuning their net electric charge[6].
 A further derivatization of this unusual amine with 3-azidopropanoic acid, 3-mercaptopropanoic acid, or 4-pentynoic acid,
 provides a di-sulfonated linker that is reactive in either “click” reactions (1,3-dipolar cycloadditions), SNAr or Sonogashira
 cross-couplings[1].
References:
 1. Chem.-Eur., J., 2013, 19, 1686.
 2. New J. Chem., 2013, 37, 1016.
 3. Dyes Pigm., 2014, 110, 270.
 4. Tetrahedron Lett., 2010, 51, 3304.
 5. Chem. Commun., 2011, 47, 9702.
 6. Bioconjugate Chem., 2014, 25, 1000.