Chloro{(R)-(-)-1,13-bis(diphenylphosphino)-7,8-dihydro-6H-dibenzo[f,h][1,5]dioxonin}(p-cymene)ruthenium(II) chloride (R)-C3-TUNEPHOS-Ru

Technical Notes:
1. New generation of chiral biaryl phosphine ligands with tunable dihedral angles. The ability to
modify the dihedral angle allows for the fine tuning of the catalyst system and optimization of enantioselectivity. See 15-0175.
2.Ru-C3-TUNEPHOS complexes are used for asymmetric hydrogenation of ß-ketoesters , enol acetates-, cyclic ß-amino acids, a-phthalimide ketones . and a-keto esters .
References:
1. J. Org.Chem., 2000, 65, 6223.
2.Org. Lett., 2002, 4, 4495.
3.J. Am. Chem. Soc., 2003, 125, 9570. . 4.J.Am. Chem. Soc., 2004, 126, 1626.
5.Synlett., 2006, 126, 1169.