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Sku CI30050_1_G
Chem Impex
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Product Information

Product Name
2'-Deoxy-2'-fluorocytidine
Brand Name
Chem Impex
Product Number
30050
CAS
10212-20-1
Certificate of Analysis (COA)​
COA not found

General Information

PubChem CID
101507
IUPAC Name
4-amino-1-(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-ylpyrimidin-2-one
InChI Key
NVZFZMCNALTPBY-XVFCMESISA-N
SMILES
C1=CN(C(=O)N=C1N)C@H2C@@H(C@@H(C@H(O2)CO)O)F

Application

2'-Deoxy-2'-fluorocytidine is widely utilized in research focused on:

Antiviral Drug Development: This compound is a key building block in the synthesis of antiviral nucleosides, which are crucial for developing treatments against viral infections like HIV and Hepatitis.

Cancer Research: It is studied for its potential in cancer therapies, particularly in designing nucleoside analogs that can inhibit tumor growth by interfering with DNA synthesis in cancer cells.

Genetic Studies: Researchers use this compound to explore the mechanisms of DNA replication and repair, providing insights into genetic stability and mutation processes.

Pharmaceutical Formulations: It is incorporated into drug formulations to enhance the efficacy of existing medications, offering improved therapeutic outcomes with potentially fewer side effects.

Biotechnology Applications: The compound is utilized in the development of novel biotechnological tools, such as in the design of targeted delivery systems for gene therapy, enhancing precision in medical treatments.

References

Conjugation of hydrophobic drugs to motile pRNA 4WJ nanoparticles for spontaneous tumor targeting and undetectable toxicity

Publication Name: Nature Protocols
Publication Date: 2026-02-03
DOI: 10.1038/s41596-025-01306-w

Nanobody-Oligonucleotide Conjugates (NucleoBodies): The Next Frontier in Oligonucleotide Therapy

Publication Name: Pharmaceutical Research
Publication Date: 2025-02
DOI: 10.1007/s11095-025-03829-z

Engineering siRNA therapeutics: challenges and strategies

Publication Name: Journal of Nanobiotechnology
Publication Date: 2023-10-18
DOI: 10.1186/s12951-023-02147-z

Synthesis, antiviral activity, and computational study of β-d-xylofuranosyl nucleoside phosphonates

Publication Name: European Journal of Medicinal Chemistry
Publication Date: 2023-07-05
DOI: 10.1016/j.ejmech.2023.115379

2- and 3-Fluoro-3-deaza-1′,6′-isoneplanocin: Synthesis and antiviral properties (including Ebola and Marburg)

Publication Name: Bioorganic & Medicinal Chemistry Letters
Publication Date: 2023-04-01
DOI: 10.1016/j.bmcl.2023.129219