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Sku CI30049_5_G
Chem Impex
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Product Information

Product Name
2'-Deoxy-2'-fluorouridine
Brand Name
Chem Impex
Product Number
30049
CAS
784-71-4
Certificate of Analysis (COA)​
COA not found

General Information

PubChem CID
150851
IUPAC Name
1-(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-ylpyrimidine-2,4-dione
InChI Key
UIYWFOZZIZEEKJ-XVFCMESISA-N
SMILES
C1=CN(C(=O)NC1=O)C@H2C@@H(C@@H(C@H(O2)CO)O)F

Application

2'-Deoxy-2'-fluorouridine is widely utilized in research focused on:

Antiviral Drug Development: This compound is a key player in the synthesis of antiviral medications, particularly those targeting viral infections like HIV and hepatitis. Its fluorine substitution enhances the efficacy of nucleoside analogs.

Cancer Research: It serves as a building block for developing chemotherapeutic agents. Researchers leverage its properties to create drugs that can inhibit tumor growth and improve treatment outcomes.

Genetic Studies: Used in molecular biology, it aids in the study of RNA and DNA mechanisms. Its incorporation into nucleic acids allows scientists to investigate gene expression and regulation.

Diagnostic Tools: The compound is employed in the development of imaging agents for PET scans, helping in the early detection of cancers and other diseases through enhanced imaging techniques.

Pharmaceutical Formulations: It is utilized in formulating novel drug delivery systems, improving the bioavailability and stability of therapeutic agents, which is crucial for effective patient treatment.

References

Nucleic acid drugs: recent progress and future perspectives

Publication Name: Signal Transduction and Targeted Therapy
Publication Date: 2024-11-29
DOI: 10.1038/s41392-024-02035-4

Current Transport Systems and Clinical Applications for Small Interfering RNA (siRNA) Drugs

Publication Name: Molecular Diagnosis & Therapy
Publication Date: 2018-06-20
DOI: 10.1007/s40291-018-0338-8

Evaluation of 2′-α-fluorine modified nucleoside phosphonates as potential inhibitors of HCV polymerase

Publication Name: Bioorganic & Medicinal Chemistry Letters
Publication Date: 2013-06-01
DOI: 10.1016/j.bmcl.2013.03.095

New insights on nucleoside 2′-deoxyribosyltransferases: a versatile Biocatalyst for one-pot one-step synthesis of nucleoside analogs

Publication Name: Applied Microbiology and Biotechnology
Publication Date: 2013-03-26
DOI: 10.1007/s00253-013-4816-y