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Product Information

Product Name
4-tert-Butylphenylboronic acid
Brand Name
Chem Impex
Product Number
28458
CAS
123324-71-0
Certificate of Analysis (COA)​
COA not found

General Information

PubChem CID
2734320
IUPAC Name
(4-tert-butylphenyl)boronic acid
InChI Key
MNJYZNVROSZZQC-UHFFFAOYSA-N
SMILES
B(C1=CC=C(C=C1)C(C)(C)C)(O)O

Application

4-tert-Butylphenylboronic acid is widely utilized in research focused on:

Organic Synthesis: This compound serves as a key reagent in Suzuki-Miyaura cross-coupling reactions, allowing chemists to create complex organic molecules efficiently. Its stability and reactivity make it a preferred choice for building diverse carbon frameworks.

Pharmaceutical Development: In the pharmaceutical industry, it is employed in the synthesis of biologically active compounds, particularly in the development of anti-cancer drugs. Its ability to form stable complexes with various substrates enhances the efficacy of drug candidates.

Material Science: This chemical is used in the production of advanced materials, such as polymers and nanomaterials. Its boronic acid functionality allows for the formation of dynamic covalent bonds, which can improve material properties like strength and flexibility.

Bioconjugation: Researchers utilize it for bioconjugation processes, where it helps attach biomolecules to surfaces or other molecules. This application is crucial in developing biosensors and targeted drug delivery systems.

Environmental Chemistry: It plays a role in environmental monitoring, particularly in detecting and quantifying phenolic compounds in water samples. Its sensitivity and specificity make it an effective tool for ensuring water quality.

References

Exploring the Nonlinear Optical Properties of Difluorobenzyl Derivatives: Synthesis and DFT Analysis

Publication Name: Structural Chemistry
Publication Date: 2025-07-04
DOI: 10.1007/s11224-025-02554-y

Enantioselective Chan–Lam S-arylation of sulfenamides

Publication Name: Nature Catalysis
Publication Date: 2024-09-09
DOI: 10.1038/s41929-024-01213-5

Synthesis, crystal structure, quantum chemical computation and molecular docking analysis of 1-(4(tert-butyl)-4-methoxy-[1,1-biphenyl]-4-yl) ethenone

Publication Name: Journal of the Iranian Chemical Society
Publication Date: 2024-05-10
DOI: 10.1007/s13738-024-03032-8

Synthesis and Characterization of Fe3O4@SiO2@MgAl-LDH@Au.Pd as an Efficient and Magnetically Recyclable Catalyst for Reduction of 4-Nitrophenol and Suzuki Coupling Reactions

Publication Name: Arabian Journal for Science and Engineering
Publication Date: 2023-01-02
DOI: 10.1007/s13369-022-07543-5