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Sku CI24969_5_G
Chem Impex
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Product Information

Product Name
4-Hydroxy-8-(trifluoromethyl)quinoline
Brand Name
Chem Impex
Product Number
24969
CAS
23779-96-6
Certificate of Analysis (COA)​
COA not found

General Information

PubChem CID
90261
IUPAC Name
8-(trifluoromethyl)-1H-quinolin-4-one
InChI Key
UDRWADJLLWWJOE-UHFFFAOYSA-N
SMILES
C1=CC2=C(C(=C1)C(F)(F)F)NC=CC2=O

Application

4-Hydroxy-8-(trifluoromethyl)quinoline is widely utilized in research focused on:

Pharmaceutical Development: This compound serves as a key intermediate in the synthesis of various pharmaceuticals, particularly those targeting bacterial infections and cancer. Its unique structure enhances biological activity, making it a valuable asset in drug discovery.

Fluorescent Probes: Due to its fluorescent properties, it is used in the development of probes for biological imaging. Researchers can use these probes to visualize cellular processes in real-time, aiding in the study of disease mechanisms.

Analytical Chemistry: It acts as a reagent in analytical methods, particularly in the detection of metal ions. This application is crucial for environmental monitoring and quality control in various industries.

Material Science: The compound is explored for its potential in creating advanced materials, such as coatings and polymers, that require specific optical or electronic properties, enhancing product performance.

Agricultural Chemistry: It is being investigated for use in agrochemicals, particularly as a fungicide or herbicide, providing an eco-friendly alternative to traditional chemicals while maintaining efficacy.

References

Multimodal action of KRP203 on phosphoinositide kinases in vitro and in cells

Publication Name: Biochemical and Biophysical Research Communications
Publication Date: 2023-10-30
DOI: 10.1016/j.bbrc.2023.08.050

A quantitative high-throughput screen identifies compounds that lower expression of the SCA2-and ALS-associated gene ATXN2

Publication Name: The Journal of biological chemistry
Publication Date: 2022-08
DOI: 10.1016/j.jbc.2022.102228

A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway

Publication Name: Journal of biomolecular screening
Publication Date: 2016-07
DOI: 10.1177/1087057116635503

Design, synthesis and docking studies of new quinoline-3-carbohydrazide derivatives as antitubercular agents

Publication Name: European Journal of Medicinal Chemistry
Publication Date: 2011-11
DOI: 10.1016/j.ejmech.2011.07.033

Prediction of Genotoxicity of Chemical Compounds by Statistical Learning Methods

Publication Name: Chemical Research in Toxicology
Publication Date: 2005-06-01
DOI: 10.1021/tx049652h