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Sku CI23013_250_MG
Chem Impex
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Product Information

Product Name
Dithio-bis-succinimidyl propionate (Lomant's Reagent)
Brand Name
Chem Impex
Product Number
23013
CAS
57757-57-0
Certificate of Analysis (COA)​
COA not found

General Information

PubChem CID
93313
IUPAC Name
(2,5-dioxopyrrolidin-1-yl) 3-3-(2,5-dioxopyrrolidin-1-yl)oxy-3-oxopropyldisulfanylpropanoate
InChI Key
FXYPGCIGRDZWNR-UHFFFAOYSA-N
SMILES
C1CC(=O)N(C1=O)OC(=O)CCSSCCC(=O)ON2C(=O)CCC2=O

Application

Dithio-bis-succinimidyl propionate (Lomant's Reagent) is widely utilized in research focused on

Protein Cross-Linking: This compound is commonly used to create stable cross-links between proteins, which is essential in studying protein interactions and structures in biochemistry.

Bioconjugation: It serves as an effective tool for attaching biomolecules, such as antibodies or enzymes, to surfaces or other molecules, enhancing the functionality of diagnostic and therapeutic agents.

Drug Delivery Systems: Researchers leverage its properties to develop advanced drug delivery systems, allowing for targeted release of therapeutics, improving efficacy while minimizing side effects.

Vaccine Development: The reagent is instrumental in the formulation of vaccines by aiding in the conjugation of antigens to carriers, which can enhance immune responses.

Material Science: In materials research, it is used for modifying surfaces to improve adhesion and compatibility of various materials, which is crucial for developing new composite materials.

References

Identification and characterization of dystrophin-locus-derived testis-specific protein: A testis-specific gene within the intronic region of the rat dystrophin gene

Publication Name: The Journal of reproduction and development
Publication Date: 2024-04-04
DOI: 10.1262/jrd.2023-073

Important of MIPs as Artificial Antibodies in Cancer Detection and Monitoring

Publication Name: Molecularly Imprinted Polymers: Path to Artificial Antibodies
Publication Date: 2024
DOI: 10.1007/978-981-97-4379-7_13

Electrochemical immunoassay for one-pot detection of thyroxin (T4) and thyroid-stimulating hormone (TSH) using magnetic and Janus nanoparticles

Publication Name: Analytical and Bioanalytical Chemistry
Publication Date: 2023-05-31
DOI: 10.1007/s00216-023-04767-8

Crosslinking assay to study a specific cargo-coat interaction through a transmembrane receptor in the secretory pathway

Publication Name: PLOS ONE
Publication Date: 2022-02-10
DOI: 10.1371/journal.pone.0263617