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Sku CI01946_100_G
Chem Impex
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Product Information

Product Name
N4-Acetyl-2'-deoxycytidine
Brand Name
Chem Impex
Product Number
01946
CAS
32909-05-0
Certificate of Analysis (COA)​
COA not found

General Information

PubChem CID
11346228
IUPAC Name
N-1-(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl-2-oxopyrimidin-4-ylacetamide
InChI Key
RWYFZABPLDFELM-QXFUBDJGSA-N
SMILES
CC(=O)NC1=NC(=O)N(C=C1)C@H2CC@@H(C@H(O2)CO)O

Application

N4-Acetyl-2'-deoxycytidine is widely utilized in research focused on:

Antiviral Research: This compound is often studied for its potential in developing antiviral therapies, particularly against viruses like HIV, due to its ability to inhibit viral replication.

DNA Synthesis: It serves as a building block in the synthesis of modified nucleotides, which are crucial for creating DNA strands in genetic engineering and synthetic biology applications.

Epigenetics: Researchers use it to explore epigenetic modifications, as it can influence gene expression by altering DNA methylation patterns.

Pharmaceutical Development: The compound is investigated for its role in formulating new drugs, especially in cancer therapy, where it may enhance the efficacy of existing treatments.

Biotechnology: It is applied in various biotechnological processes, including the development of diagnostic tools and therapeutic agents, thanks to its versatility in modifying nucleic acids.

References

N4-acetyldeoxycytosine DNA modification marks euchromatin regions in Arabidopsis thaliana

Publication Name: Genome Biology
Publication Date: 2022-01-03
DOI: 10.1186/s13059-021-02578-7

A DNA adductome analysis revealed a reduction in the global level of C5-hydroxymethyl-2′-deoxycytidine in the non-tumoral upper urinary tract mucosa of urothelial carcinoma patients

Publication Name: Genes and environment : the official journal of the Japanese Environmental Mutagen Society
Publication Date: 2021-12-02
DOI: 10.1186/s41021-021-00228-9

YqfB protein from Escherichia coli: an atypical amidohydrolase active towards N4-acylcytosine derivatives

Publication Name: Scientific Reports
Publication Date: 2020-01-21
DOI: 10.1038/s41598-020-57664-w

Non-protected Synthesis of Oligonucleotides

Publication Name: Synthesis of Therapeutic Oligonucleotides
Publication Date: 2018
DOI: 10.1007/978-981-13-1912-9_1

Stereoselective formation of a cyclobutane pyrimidine dimer by using N4-acetyl protection of the cytosine base

Publication Name: Nucleic acids symposium series (2004)
Publication Date: 2008-09-01
DOI: 10.1093/nass/nrn222