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Sku CI00664_25_G
Chem Impex
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Product Information

Product Name
5-Fluorouridine
Brand Name
Chem Impex
Product Number
00664
CAS
316-46-1
Certificate of Analysis (COA)​
COA not found

General Information

PubChem CID
9427
IUPAC Name
1-(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl-5-fluoropyrimidine-2,4-dione
InChI Key
FHIDNBAQOFJWCA-UAKXSSHOSA-N
SMILES
C1=C(C(=O)NC(=O)N1C@H2C@@H(C@@H(C@H(O2)CO)O)O)F

Application

5-Fluorouridine is widely utilized in research focused on:

Antiviral Research: It serves as a crucial compound in developing antiviral therapies, particularly against RNA viruses. Its ability to inhibit viral replication makes it a valuable tool in drug discovery.

Cancer Treatment: This compound is investigated for its potential in cancer therapies, especially in combination with other chemotherapeutic agents. It can enhance the efficacy of treatments by targeting cancer cell metabolism.

RNA Studies: Researchers use it to study RNA metabolism and function. Its incorporation into RNA allows scientists to explore RNA processing and the effects of fluorinated nucleotides.

Pharmaceutical Development: It plays a role in the formulation of new drugs, particularly in the design of nucleoside analogs that can improve therapeutic outcomes in various diseases.

Diagnostic Tools: The compound is also being explored for use in diagnostic applications, where its unique properties can aid in the detection of specific viral infections or cancer markers.

References

The mTORC2 component SIN1 post-transcriptionally regulates TYMS levels and modulates P53 activity in response to 5-FU chemotherapy

Publication Name: Cell communication and signaling : CCS
Publication Date: 2026-01-28
DOI: 10.1186/s12964-025-02640-y

S113 | SWISSPHARMA24 | 2024 Swiss Pharmaceutical List with Metabolites

Publication Date: 2026
DOI: 10.5281/zenodo.10501043

Application of Small Molecule Fluorescent Probe in Tumor Diagnosis and Treatment

Publication Name: Functional Organic Materials for Tumor Diagnostics and Therapy
Publication Date: 2026
DOI: 10.1007/978-981-96-9478-5_2

Uridine-sensitized screening identifies demethoxy-coenzyme Q and NUDT5 as regulators of nucleotide synthesis

Publication Name: Nature Metabolism
Publication Date: 2025-11-13
DOI: 10.1038/s42255-025-01419-2

Metabolic fingerprinting to elucidate the biodegradation of phosphonoacetic acid and its impact on Penicillium metabolism

Publication Name: Biodegradation
Publication Date: 2025-09-29
DOI: 10.1007/s10532-025-10192-8