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Sku CI00610_5_G
Chem Impex
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Product Information

Product Name
5'-O-(4,4'-dimethoxytrityl) uridine
Brand Name
Chem Impex
Product Number
00610
CAS
81246-79-9
Certificate of Analysis (COA)​
COA not found

General Information

PubChem CID
11763309
IUPAC Name
1-(2R,3R,4S,5R)-5-bis(4-methoxyphenyl)-phenylmethoxymethyl-3,4-dihydroxyoxolan-2-ylpyrimidine-2,4-dione
InChI Key
PCFSNQYXXACUHM-YULOIDQLSA-N
SMILES
COC1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)OCC@@H4C@H(C@H(C@@H(O4)N5C=CC(=O)NC5=O)O)O

Application

5'-O-(4,4'-dimethoxytrityl) uridine is widely utilized in research focused on:

Nucleic Acid Synthesis: This compound serves as a key building block in the synthesis of RNA oligonucleotides, facilitating the development of various RNA-based therapeutics and diagnostics.

Gene Therapy: It plays a crucial role in gene therapy applications, where modified RNA is used to deliver genetic material into cells, potentially correcting genetic disorders.

Antisense Oligonucleotides: The compound is instrumental in creating antisense oligonucleotides, which can inhibit gene expression and are being explored for treating diseases like cancer and viral infections.

Research in Molecular Biology: It is commonly used in molecular biology research to study RNA functions and interactions, helping scientists understand cellular processes and develop new biotechnological applications.

Pharmaceutical Development: The compound is valuable in the pharmaceutical industry for developing RNA-based drugs, offering a targeted approach to treatment with potentially fewer side effects compared to traditional small molecules.

References

Synthesis and in vitro growth inhibitory activity of novel silyl- and trityl-modified nucleosides

Publication Name: Bioorganic & Medicinal Chemistry
Publication Date: 2016-06-15
DOI: 10.1016/j.bmc.2016.04.036

Catalyst recognition of cis-1,2-diols enables site-selective functionalization of complex molecules.

Publication Name: Nature Chemistry
Publication Date: 2013-08-11
DOI: 10.1038/nchem.1726