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Sku CI00408_1_G
Chem Impex
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Product Information

Product Name
5-Iodo-2'-deoxycytidine
Brand Name
Chem Impex
Product Number
00408
CAS
611-53-0
Certificate of Analysis (COA)​
COA not found

General Information

PubChem CID
65050
IUPAC Name
4-amino-1-(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl-5-iodopyrimidin-2-one
InChI Key
WEVJJMPVVFNAHZ-RRKCRQDMSA-N
SMILES
C1C@@H(C@H(OC@H1N2C=C(C(=NC2=O)N)I)CO)O

Application

5-Iodo-2'-deoxycytidine is widely utilized in research focused on:

Antiviral Research: This compound is effective in studying viral replication mechanisms, particularly in the development of antiviral therapies against diseases like HIV.

DNA Synthesis Studies: It serves as a valuable tool in molecular biology for incorporating iodine into DNA, helping researchers understand the effects of halogenation on nucleic acids.

Cancer Research: The compound is explored for its potential in cancer treatments, as it can interfere with DNA synthesis in rapidly dividing cells, offering insights into targeted therapies.

Pharmaceutical Development: It plays a role in the synthesis of nucleoside analogs, which are crucial in developing new drugs for various diseases, enhancing therapeutic options.

Genetic Engineering: This chemical is used in CRISPR and other gene-editing technologies, providing researchers with a means to modify genetic material with precision.

References

Rapid plugged flow synthesis of nucleoside analogues via Suzuki-Miyaura coupling and heck Alkenylation of 5-Iodo-2’-deoxyuridine (or cytidine)

Publication Name: Journal of Flow Chemistry
Publication Date: 2023-03-16
DOI: 10.1007/s41981-023-00265-1

EcoRII Restriction Endonuclease Forms Specific Contacts to the Bases of Its Target Sequence Flipped from DNA in a Transition Complex with Photoactivatable Substrates

Publication Name: Russian Journal of Bioorganic Chemistry
Publication Date: 2021-03
DOI: 10.1134/s106816202102014x

DCTPP1 prevents a mutator phenotype through the modulation of dCTP, dTTP and dUTP pools

Publication Name: Cellular and molecular life sciences : CMLS
Publication Date: 2019-08-03
DOI: 10.1007/s00018-019-03250-x

Synthesis of Site-Specific Crown Ether Adducts to DNA Abasic Sites: 8-Oxo-7,8-Dihydro-2′-Deoxyguanosine and 2′-Deoxycytidine

Publication Name: Methods in molecular biology (Clifton, N.J.)
Publication Date: 2019
DOI: 10.1007/978-1-4939-9216-4_2

New Synthetic Route to CY5-Labeled 2'-Deoxycytidine- 5'-Triphosphates Using Sonogashira Reaction

Publication Name: Russian Journal of Bioorganic Chemistry
Publication Date: 2018-03
DOI: 10.1134/s1068162018020103