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Product Information

Product Name
Na-Fmoc-L-asparagine
Brand Name
Chem Impex
Product Number
00228
CAS
71989-16-7
Certificate of Analysis (COA)​
COA not found

General Information

PubChem CID
2724774
IUPAC Name
(2S)-4-amino-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-oxobutanoic acid
InChI Key
YUGBZNJSGOBFOV-INIZCTEOSA-N
SMILES
C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)NC@@H(CC(=O)N)C(=O)O

Application

Na-Fmoc-L-asparagine is widely utilized in research focused on:

Peptide Synthesis: This compound serves as a key building block in the synthesis of peptides, allowing for the incorporation of asparagine residues. Its protective Fmoc group facilitates efficient coupling reactions.

Drug Development: In pharmaceutical research, it is used to create peptide-based drugs, particularly in areas targeting neurological disorders, where asparagine plays a crucial role in neurotransmission.

Bioconjugation: Na-Fmoc-L-asparagine is employed in bioconjugation techniques, linking peptides to various biomolecules, enhancing drug delivery systems and improving therapeutic efficacy.

Protein Engineering: This compound aids in the design of modified proteins with specific functionalities, which can be crucial for developing novel enzymes or therapeutic proteins.

Analytical Chemistry: It is used in analytical applications, such as mass spectrometry, to study peptide fragmentation patterns, helping researchers understand peptide behavior and stability.

References

Synthesis of Azido Acids and Their Application in the Preparation of Complex Peptides

Publication Name: Synthesis
Publication Date: 2020-11-09
DOI: 10.1055/s-0040-1707314

Histone Protein Epitope Mapping for Autoantibody Recognition in Rheumatoid Arthritis.

Publication Name: Methods in Molecular Biology
Publication Date: 2018-12-12
DOI: 10.1007/978-1-4939-8949-2_18

Identification of Chaoborus kairomone chemicals that induce defences in Daphnia

Publication Name: Nature Chemical Biology
Publication Date: 2018-11-14
DOI: 10.1038/s41589-018-0164-7

Chemo-enzymatic synthesis of a glycosylated peptide containing a complex N-glycan based on unprotected oligosaccharides by using DMT-MM and Endo-M

Publication Name: Glycoconjugate Journal
Publication Date: 2017-05-18
DOI: 10.1007/s10719-017-9770-y

Identification of noncovalent proteasome inhibitors with high selectivity for chymotrypsin-like activity by a multistep structure-based virtual screening

Publication Name: European Journal of Medicinal Chemistry
Publication Date: 2016-10-04
DOI: 10.1016/j.ejmech.2016.05.049