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Sku CI00191_100_G
Chem Impex
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Product Information

Product Name
5-Iodo-2'-deoxyuridine
Brand Name
Chem Impex
Product Number
00191
CAS
54-42-2
Certificate of Analysis (COA)​
COA not found

General Information

PubChem CID
5905
IUPAC Name
1-(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl-5-iodopyrimidine-2,4-dione
InChI Key
XQFRJNBWHJMXHO-RRKCRQDMSA-N
SMILES
C1C@@H(C@H(OC@H1N2C=C(C(=O)NC2=O)I)CO)O

Application

5-Iodo-2'-deoxyuridine is widely utilized in research focused on:

Antiviral Research: This compound is effective in studying viral replication, particularly in the development of antiviral therapies against herpes simplex virus and other DNA viruses.

Cancer Treatment: It serves as a nucleoside analog in cancer research, helping to understand its role in inhibiting tumor cell proliferation and enhancing the efficacy of chemotherapy.

Genetic Studies: Researchers use it to explore DNA synthesis and repair mechanisms, providing insights into genetic disorders and potential therapeutic interventions.

Pharmaceutical Development: This compound is a valuable tool in drug formulation, particularly for creating targeted therapies that require precise nucleoside modifications.

Diagnostic Applications: It can be employed in molecular imaging techniques, aiding in the detection and monitoring of certain diseases through its incorporation into DNA.

References

Antiviral drug discovery and development: challenges and future directions

Publication Name: Signal Transduction and Targeted Therapy
Publication Date: 2026-02-25
DOI: 10.1038/s41392-025-02539-7

Utilizing pH-sensitive nanoparticles in cancer radiotherapy: mechanisms and therapeutic potential

Publication Name: Journal of Nanoparticle Research
Publication Date: 2026-01-28
DOI: 10.1007/s11051-026-06553-w

Oncogenic p53 induces mitotic errors in lung cancer cells by recopying DNA replication forks conferring targetable proliferation advantage

Publication Name: Cell death and differentiation
Publication Date: 2026-01-26
DOI: 10.1038/s41418-026-01670-4

Antiviral Drug Design: Past, Presence, and Future

Publication Name: Advances in experimental medicine and biology
Publication Date: 2026
DOI: 10.1007/978-3-032-03402-1_37