EPZ015666, 98%, an orally available inhibitor of PRMT5

Name: EPZ015666, 98%, an orally available inhibitor of PRMT5 | 1616391-65-1
Brand: J&K Chemical
SKU: JK990755_2_MG
Price: 142.2 USD
Availability: OutOfStock

Cat. No JK990755_2_MG

Vendor: J&K Chemical

Product Information

Product Name

EPZ015666, 98%, an orally available inhibitor of PRMT5

Brand Name

J&K

Product Number

990755

CAS

1616391-65-1

Molecular Formula

C20H25N5O3

Molecular Weight

383.44

SDS Document

View/Download

Certificate of Analysis (COA)

COA not found

General Information

Synonyms

GSK3235025

PubChem CID

90241673

IUPAC Name

N-(2S)-3-(3,4-dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl-6-(oxetan-3-ylamino)pyrimidine-4-carboxamide

InChI Key

ZKXZLIFRWWKZRY-KRWDZBQOSA-N

SMILES

C1CN(CC2=CC=CC=C21)CC@H(CNC(=O)C3=CC(=NC=N3)NC4COC4)O

Safety Information

Storage Condition

Freezer -20℃

References Data Source From Pubchem

Discovery of a Novel Benzimidazole Derivative Targeting Histone Deacetylase to Induce Ferroptosis and Trigger Immunogenic Cell Death

Publication Name: Journal of Medicinal Chemistry

Publication Date: 2024-08-15

DOI: 10.1021/acs.jmedchem.4c00729

Synthesis and biological evaluation of 1-phenyl-tetrahydro-β-carboline-based first dual PRMT5/EGFR inhibitors as potential anticancer agents

Publication Name: European Journal of Medicinal Chemistry

Publication Date: 2024-04-05

DOI: 10.1016/j.ejmech.2024.116341

Overview of the development of protein arginine methyltransferase modulators: Achievements and future directions

Publication Name: European Journal of Medicinal Chemistry

Publication Date: 2024-03-05

DOI: 10.1016/j.ejmech.2024.116212

Discovery of tetrahydroisoquinolineindole derivatives as first dual PRMT5 inhibitors/hnRNP E1 upregulators: Design, synthesis and biological evaluation

Publication Name: European Journal of Medicinal Chemistry

Publication Date: 2023-10-05

DOI: 10.1016/j.ejmech.2023.115625

Identification of a Protein Arginine Methyltransferase 7 (PRMT7)/Protein Arginine Methyltransferase 9 (PRMT9) Inhibitor

Publication Name: Journal of Medicinal Chemistry

Publication Date: 2023-08-10

DOI: 10.1021/acs.jmedchem.3c01030

EPZ015666, 98%, an orally available inhibitor of PRMT5

Product Information

General Information

Safety Information

References Data Source From Pubchem

Discovery of a Novel Benzimidazole Derivative Targeting Histone Deacetylase to Induce Ferroptosis and Trigger Immunogenic Cell Death

Synthesis and biological evaluation of 1-phenyl-tetrahydro-β-carboline-based first dual PRMT5/EGFR inhibitors as potential anticancer agents

Overview of the development of protein arginine methyltransferase modulators: Achievements and future directions

Discovery of tetrahydroisoquinolineindole derivatives as first dual PRMT5 inhibitors/hnRNP E1 upregulators: Design, synthesis and biological evaluation

Identification of a Protein Arginine Methyltransferase 7 (PRMT7)/Protein Arginine Methyltransferase 9 (PRMT9) Inhibitor