3-Isobutyl-1-methylxanthine, 99%, a broad-spectrum phosphodiesterase (PDE) inhibitor, with IC50s of 6.5, 26.3 and 31.7 μM for PDE3, PDE4 and PDE5, respectively

Name: 3-Isobutyl-1-methylxanthine, 99%, a broad-spectrum phosphodiesterase (PDE) inhibitor, with IC50s of 6.5, 26.3 and 31.7 μM for PDE3, PDE4 and PDE5, respectively | 28822-58-4
Brand: J&K Chemical
SKU: JK312460_1_G
Price: 244.0 USD
Availability: InStock

Cat. No JK312460_1_G

Vendor: J&K Chemical

Product Information

Product Name

3-Isobutyl-1-methylxanthine, 99%, a broad-spectrum phosphodiesterase (PDE) inhibitor, with IC50s of 6.5, 26.3 and 31.7 μM for PDE3, PDE4 and PDE5, respectively

Brand Name

J&K

Product Number

312460

CAS

28822-58-4

Molecular Formula

C10H14N4O2

Molecular Weight

222.25

Certificate of Analysis (COA)

COA not found

General Information

Synonyms

1-Methyl-3-isobutylxanthine
3,7-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione
3-Isobutyl-1-methyl-2,6(1H,3H)-purinedione

PubChem CID

3758

IUPAC Name

1-methyl-3-(2-methylpropyl)-7H-purine-2,6-dione

InChI Key

APIXJSLKIYYUKG-UHFFFAOYSA-N

SMILES

CC(C)CN1C2=C(C(=O)N(C1=O)C)NC=N2

Properties

Melting Point

200-201

Safety Information

GHS Symbols

Signal Word

Warning

Hazard Statement

H302

Precautionary Statement

P264

P270

P330

P501

P301+P317

Storage Condition

Freezer -20℃

References Data Source From Pubchem

MIF tautomerase inhibitor 4-IPP alleviates HFD-induced obesity by restoring CD137-mediated browning of white adipocytes in mice

Publication Name: Acta Pharmacologica Sinica

Publication Date: 2026-02-25

DOI: 10.1038/s41401-026-01755-3

Fatty acids promote uncoupled respiration via ATP/ADP carriers in white adipocytes

Publication Name: Nature Metabolism

Publication Date: 2026-02-23

DOI: 10.1038/s42255-026-01467-2

RFX6 expression is central to the development and function of the neuroendocrine compartments of the pancreas and intestine and strongly affects diabetes risk

Publication Name: Diabetology International

Publication Date: 2026-02-17

DOI: 10.1007/s13340-025-00867-1

Epigenetic regulation of adipogenesis on dental stem cells: a focus on histone modifications

Publication Name: Molecular Biology Reports

Publication Date: 2026-02-09

DOI: 10.1007/s11033-026-11536-0

Associations between isoflavone composition and enzyme inhibition in Cheonggukjang upgraded by mycelial co-fermentation

Publication Name: Food Science and Biotechnology

Publication Date: 2026-02-09

DOI: 10.1007/s10068-026-02105-z

3-Isobutyl-1-methylxanthine, 99%, a broad-spectrum phosphodiesterase (PDE) inhibitor, with IC50s of 6.5, 26.3 and 31.7 μM for PDE3, PDE4 and PDE5, respectively

Product Information

General Information

Properties

Safety Information

References Data Source From Pubchem

MIF tautomerase inhibitor 4-IPP alleviates HFD-induced obesity by restoring CD137-mediated browning of white adipocytes in mice

Fatty acids promote uncoupled respiration via ATP/ADP carriers in white adipocytes

RFX6 expression is central to the development and function of the neuroendocrine compartments of the pancreas and intestine and strongly affects diabetes risk

Epigenetic regulation of adipogenesis on dental stem cells: a focus on histone modifications

Associations between isoflavone composition and enzyme inhibition in Cheonggukjang upgraded by mycelial co-fermentation