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Sku CI14096_5_G
Chem Impex
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Product Information

Product Name
5'-O-(4,4'-dimethoxytrityl) thymidine (synthetic)
Brand Name
Chem Impex
Product Number
14096
CAS
40615-39-2
Certificate of Analysis (COA)​
COA not found

General Information

PubChem CID
162419
IUPAC Name
1-(2R,4S,5R)-5-bis(4-methoxyphenyl)-phenylmethoxymethyl-4-hydroxyoxolan-2-yl-5-methylpyrimidine-2,4-dione
InChI Key
UBTJZUKVKGZHAD-UPRLRBBYSA-N
SMILES
CC1=CN(C(=O)NC1=O)C@H2CC@@H(C@H(O2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)O

Application

5'-O-(4,4'-dimethoxytrityl) thymidine (synthetic) is widely utilized in research focused on:

Nucleic Acid Synthesis: This compound serves as a key building block in the synthesis of oligonucleotides, which are essential for various genetic engineering applications, including gene therapy and CRISPR technology.

Pharmaceutical Development: It plays a significant role in the development of antiviral drugs, particularly those targeting viral replication processes, enhancing the efficacy of treatments for diseases like HIV and hepatitis.

Biotechnology Research: Researchers use it in the production of modified nucleotides, which can improve the stability and functionality of RNA molecules in therapeutic applications.

Diagnostic Tools: This compound is utilized in the creation of probes and primers for PCR (Polymerase Chain Reaction), facilitating the rapid detection of pathogens in clinical diagnostics.

Gene Expression Studies: It aids in the study of gene expression by enabling the synthesis of labeled nucleotides, which are crucial for tracking and analyzing RNA in various biological processes.

References

Clinical efficacy of Sep-Pak® assisted one pot automated synthesis of pharmaceutical grade [18F]FLT using 5′-O-(benzoyl)-2,3′-anhydrothymidine precursor

Publication Name: Journal of Radioanalytical and Nuclear Chemistry
Publication Date: 2021-01-04
DOI: 10.1007/s10967-020-07531-9

The case of triethylammonium cation loss during purification of certain nucleotide analogues: a cautionary note

Publication Name: Analytical and Bioanalytical Chemistry
Publication Date: 2014-12-27
DOI: 10.1007/s00216-014-8397-0

New acid photogenerators based on thioxanthen-9-one sulfonium derivatives for detritylation in the oligonucleotide synthesis

Publication Name: Russian Chemical Bulletin
Publication Date: 2011-03
DOI: 10.1007/s11172-011-0087-x

Novel antisense oligonucleotides containing hydroxamate linkages: targeted iron-triggered chemical nucleases

Publication Name: Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine
Publication Date: 2009-01-28
DOI: 10.1007/s10534-009-9206-7

Horner–Wadsworth–Emmons Reaction of Phosphonamidates and Thiophosphonamidates

Publication Name: Science of Synthesis
Publication Date: 2009