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Chem Impex
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Product Information

Product Name
3'-O-Acetylthymidine
Brand Name
Chem Impex
Product Number
02103
CAS
21090-30-2
Certificate of Analysis (COA)​
COA not found

General Information

PubChem CID
464365
IUPAC Name
(2R,3S,5R)-2-(hydroxymethyl)-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl acetate
InChI Key
IRFKBRPHBYCMQU-IVZWLZJFSA-N
SMILES
CC1=CN(C(=O)NC1=O)C@H2CC@@H(C@H(O2)CO)OC(=O)C

Application

3'-O-Acetylthymidine is widely utilized in research focused on:

Nucleoside Synthesis: This compound serves as a key intermediate in the synthesis of various nucleosides, which are essential for DNA and RNA research. Its acetyl group enhances stability and solubility, making it easier to work with in laboratory settings.

Antiviral Research: It is explored for its potential antiviral properties, particularly against viruses that affect nucleic acid metabolism. Researchers are investigating its efficacy in developing new antiviral therapies.

Drug Development: The compound is being studied for its role in creating prodrugs, which can improve the bioavailability of therapeutic agents. This application is crucial in the pharmaceutical industry for enhancing drug effectiveness.

Biochemical Assays: It is used in various biochemical assays to study enzyme activity related to nucleic acid processes. This application helps researchers understand fundamental biological mechanisms.

Gene Therapy: 3'-O-Acetylthymidine is being researched for its potential use in gene therapy applications, where it may help deliver genetic material more effectively into cells, addressing challenges in current gene delivery methods.

References

N-Glycosides

Publication Name: Synthesis and Characterization of Glycosides
Publication Date: 2022
DOI: 10.1007/978-3-030-97854-9_3

Acetylated Nucleoside Derivatives from a Shallow-Water Marine Bivalve Codakia orbicularis

Publication Name: Chemistry of Natural Compounds
Publication Date: 2019-07-29
DOI: 10.1007/s10600-019-02814-4

Piperacillin Population Pharmacokinetics and Dosing Regimen Optimization in Critically Ill Children with Normal and Augmented Renal Clearance

Publication Name: Clinical Pharmacokinetics
Publication Date: 2018-06-04
DOI: 10.1007/s40262-018-0682-1

N-glycosides

Publication Name: Synthesis and Characterization of Glycosides
Publication Date: 2016
DOI: 10.1007/978-3-319-32310-7_3

Lipophilic prodrugs of nucleoside triphosphates as biochemical probes and potential antivirals

Publication Name: Nature Communications
Publication Date: 2015-10-27
DOI: 10.1038/ncomms9716