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Sku CI00134_5_G
Chem Impex
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Product Information

Product Name
5'-O-(4,4'-dimethoxytrityl)thymidine
Brand Name
Chem Impex
Product Number
00134
CAS
40615-39-2
Certificate of Analysis (COA)​
COA not found

General Information

PubChem CID
162419
IUPAC Name
1-(2R,4S,5R)-5-bis(4-methoxyphenyl)-phenylmethoxymethyl-4-hydroxyoxolan-2-yl-5-methylpyrimidine-2,4-dione
InChI Key
UBTJZUKVKGZHAD-UPRLRBBYSA-N
SMILES
CC1=CN(C(=O)NC1=O)C@H2CC@@H(C@H(O2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)O

Application

5'-O-(4,4'-dimethoxytrityl)thymidine is widely utilized in research focused on:

Nucleic Acid Synthesis: This compound serves as a key building block in the synthesis of oligonucleotides, which are essential for genetic research, including gene editing and PCR applications.

Antisense Oligonucleotide Development: It is used in the development of antisense oligonucleotides, which can inhibit gene expression and are valuable in therapeutic applications for various diseases.

Drug Development: The compound plays a role in the formulation of nucleotide analogs, which can be used in antiviral and anticancer drug development, providing targeted treatment options.

Biotechnology Research: It is utilized in the production of modified nucleotides for various biotechnological applications, enhancing the efficiency of molecular cloning and sequencing techniques.

Diagnostic Tools: This chemical is integral in the creation of diagnostic assays, such as those used in detecting viral infections, thereby improving patient outcomes through timely diagnosis.

References

Clinical efficacy of Sep-Pak® assisted one pot automated synthesis of pharmaceutical grade [18F]FLT using 5′-O-(benzoyl)-2,3′-anhydrothymidine precursor

Publication Name: Journal of Radioanalytical and Nuclear Chemistry
Publication Date: 2021-01-04
DOI: 10.1007/s10967-020-07531-9

The case of triethylammonium cation loss during purification of certain nucleotide analogues: a cautionary note

Publication Name: Analytical and Bioanalytical Chemistry
Publication Date: 2014-12-27
DOI: 10.1007/s00216-014-8397-0

New acid photogenerators based on thioxanthen-9-one sulfonium derivatives for detritylation in the oligonucleotide synthesis

Publication Name: Russian Chemical Bulletin
Publication Date: 2011-03
DOI: 10.1007/s11172-011-0087-x

Novel antisense oligonucleotides containing hydroxamate linkages: targeted iron-triggered chemical nucleases

Publication Name: Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine
Publication Date: 2009-01-28
DOI: 10.1007/s10534-009-9206-7

Horner–Wadsworth–Emmons Reaction of Phosphonamidates and Thiophosphonamidates

Publication Name: Science of Synthesis
Publication Date: 2009