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Product Information

Product Name
N-Hydroxysuccinimide
Brand Name
Chem Impex
Product Number
00182
CAS
6066-82-6
Certificate of Analysis (COA)​
COA not found

General Information

PubChem CID
80170
IUPAC Name
1-hydroxypyrrolidine-2,5-dione
InChI Key
NQTADLQHYWFPDB-UHFFFAOYSA-N
SMILES
C1CC(=O)N(C1=O)O

Application

N-Hydroxysuccinimide is widely utilized in research focused on:

Bioconjugation: It serves as a key reagent for attaching biomolecules, such as proteins or peptides, to surfaces or other molecules, enhancing the development of targeted drug delivery systems.

Protein Modification: This compound is commonly used to modify proteins for various applications, including the creation of stable protein conjugates that are essential in vaccine development and diagnostics.

Fluorescent Labeling: Researchers use N-Hydroxysuccinimide to create fluorescently labeled compounds, which are crucial for imaging and tracking biological processes in live cells.

Polymer Chemistry: It plays a significant role in the synthesis of functionalized polymers, which can be used in drug delivery, tissue engineering, and other advanced materials.

Diagnostics: The compound is integral in developing assays and diagnostic kits, particularly in the detection of biomarkers, providing reliable results in clinical settings.

References

High-affinity ssDNA aptamer and chemiluminescent aptasensor for TIMP-1 detection in human serum

Publication Name: Analytical sciences : the international journal of the Japan Society for Analytical Chemistry
Publication Date: 2025-01-01
DOI: 10.1007/s44211-024-00673-w

Deciphering Cancer Complexity: Integrative Proteogenomics and Proteomics Approaches for Biomarker Discovery

Publication Name: Methods in molecular biology (Clifton, N.J.)
Publication Date: 2025
DOI: 10.1007/978-1-0716-4152-1_12

Live-Cell Imaging of Multiple Endogenous mRNAs Using RNA Aptamers and Chemical Probes

Publication Name: Methods in molecular biology (Clifton, N.J.)
Publication Date: 2025
DOI: 10.1007/978-1-0716-4248-1_16

Determination of degradation for sulfo-SIAB, SM(PEG)2, and sulfo-GMBS by RPLC-UV analysis

Publication Name: Journal of Pharmaceutical and Biomedical Analysis
Publication Date: 2024-12-15
DOI: 10.1016/j.jpba.2024.116455

Engineering living cells with polymers for recyclable photoenzymatic catalysis

Publication Name: Nature Catalysis
Publication Date: 2024-12-11
DOI: 10.1038/s41929-024-01259-5