Fluorine-containing molecules have been widely used in modern medicines, pesticides and materials. For example, the selective addition of a fluoroalkyl group to drugs or bioactive molecules often significantly alters their metabolic stability, lipophilicity, and bioactivity. Therefore, there has been considerable interest in developing new and efficient methods to incorporate fluoroalkyl groups into organic molecules. Among them, free radical trifluoromethylation reactions of various substrates have received widespread attention in recent years due to mild reaction conditions. However, the direct introduction of CF2H and CH2F groups through free radical processes is limited [1].

      We launch sodium difluoromethanesulfinate & sodium monofluoromethanesulfinate, which help you easily introduce CH2H and CH2F:

      Cost-effective and easy to use: In the early days, Baran's group used zinc sulfide and fluorinated alkyl radioactive sources to conduct direct C-H dimethylation and monofluoromethylation of isoaromatic hydrocarbons, but the procedure for purifying zinc sulfite was very complicated; difluoromethane As a commonly used free radical difluorination reagent, sodium sulfite has low preparation yield and difficult purification; compared with them, sodium fluoromethanesulfinate & sodium monofluoromethanesulfinate are easy to operate and green;
      It has a wide range of reaction substrates and a wide range of uses: under the action of a suitable oxidant, free radical reactions occur with olefins, heteroatoms, isocyanates, aromatic heterocycles, cyclopropane, etc., to generate corresponding products containing CF2H or CH2F [1-5 ], see Figure 1;
They are all colorless solids, stable in nature, and insensitive to air and water.

Figure 1: RfSO2Na reacts with alkenes, heteroatoms, isocyanates, aromatic heterocycles, cyclopropanes, etc. in free radical reactions to generate corresponding products containing CF2H or CH2F.

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