Intraoperative fluorescence navigation is a cutting-edge technology that leverages the enhanced penetration and retention effect (EPR effect) of fluorescent dyes. These dyes accumulate in tumor tissue and emit fluorescence upon receiving excitation light, allowing for real-time visualization of tumor locations during surgery.
Figure 1 Fluorescence imaging technology has broad application prospects in intraoperative navigation due to its advantages such as easy operation, high resolution, good safety, and real-time imaging. [1]
This technique significantly improves the accuracy and safety of surgical procedures, reduces surgical trauma, and shortens recovery time. As a result, fluorescence navigation surgery has gained widespread acceptance in various surgical fields, including tumor resection, vascular surgery, and neurological surgery.
Fluorescence Classification by Emission Wavelength
Based on the emission wavelength of fluorescent contrast agents, near-infrared fluorescence can be categorized into two regions:
- Near-Infrared First Region (NIR-Ⅰ): Ranging from 700 to 1,000 nm
- Near-Infrared Second Region (NIR-Ⅱ): Ranging from 1,000 to 1,700 nm
Currently, near-infrared fluorescence navigation technologies, particularly those based on indocyanine green (ICG), have been effectively utilized to guide tumor resections.
J&K Scientific's Contribution to Intraoperative Navigation
J&K Scientific provides a range of near-infrared first zone (NIR-Ⅰ) fluorescent dyes designed to assist in intraoperative navigation. These dyes enhance the precision of surgical interventions and contribute to better patient outcomes.
Product name | CAS | item number |
---|---|---|
Indocyanine Green, dye content 90% | 3599-32-4 | 593562 |
Methylene Blue trihydrate, for bio | 7220-79-3 | 468333 |
Professor Yang Youjun’s scientific research achievements | EC series near-infrared fluorescent dyes - high fluorescence intensity and good photostability
EC835, 97%, Near-infrared fluorescent dye, liposoluble
Product name | CAS | Item number |
---|---|---|
EC835-Br, 97%, Near-infrared fluorescent dye, liposoluble EC835-Br |
/ | 9372074 |
EC835-N3, 97%, Near-infrared fluorescent dye, liposoluble EC835-N3 |
/ | 9372075 |
EC835WS, 97%, Near-infrared fluorescent dye, water-soluble EC835WS |
/ | 9189162 |
EC835-WSN3, 97%, Near-infrared fluorescent dye, water-soluble EC835-WSN3 |
/ | 9372077 |
Indocyanine green (ICG) reactive derivatives—near-infrared I-region fluorescent dyes that can modify and label biological macromolecules
The main application areas of ICG and its derivatives include:
(1) ophthalmic angiography;
(2) perfusion diagnosis of tissues and organs;
(3) sentinel lymph node biopsy of tumors;
(4) near-infrared fluorescence/photoacoustic dual-modal imaging;
(5) Photodynamic/photothermal therapy synergistic treatment[1-4]
J&K Scientific provides 15 kinds of indocyanine green (ICG) active derivatives - which can modify and label biological macromolecules with a purity of ≥95%.
Product name | CAS | Item number |
---|---|---|
ICG-COOH, 95% | 181934-09-8 | 9148080 |
ICG-Maleimide, 95% | 2143933-81-5 | 9148082 |
ICG-Tetrazine, 95% | / | 9148083 |
ICG-azide, 95% | / | 9148084 |
ICG-alkyne, 95% | 1622335-41-4 | 9148085 |
ICG-DBCO, 95% | / | 9148086 |
ICG-CBT, 95% | / | 9148087 |
ICG-Amine, 95% | 1686147-55-6 | 9148088 |
ICG-SH, 95% | 2387670-76-8 | 9148089 |