Intraoperative fluorescence navigation is a cutting-edge technology that leverages the enhanced penetration and retention effect (EPR effect) of fluorescent dyes. These dyes accumulate in tumor tissue and emit fluorescence upon receiving excitation light, allowing for real-time visualization of tumor locations during surgery. 

 

intraoperative fluorescence navigation using near-infrared fluorescent dyes for tumor detection

Figure 1 Fluorescence imaging technology has broad application prospects in intraoperative navigation due to its advantages such as easy operation, high resolution, good safety, and real-time imaging. [1]

This technique significantly improves the accuracy and safety of surgical procedures, reduces surgical trauma, and shortens recovery time. As a result, fluorescence navigation surgery has gained widespread acceptance in various surgical fields, including tumor resection, vascular surgery, and neurological surgery. 

Fluorescence Classification by Emission Wavelength

Based on the emission wavelength of fluorescent contrast agents, near-infrared fluorescence can be categorized into two regions:

  • Near-Infrared First Region (NIR-Ⅰ): Ranging from 700 to 1,000 nm
  • Near-Infrared Second Region (NIR-Ⅱ): Ranging from 1,000 to 1,700 nm

Currently, near-infrared fluorescence navigation technologies, particularly those based on indocyanine green (ICG), have been effectively utilized to guide tumor resections.

J&K Scientific's Contribution to Intraoperative Navigation

J&K Scientific provides a range of near-infrared first zone (NIR-Ⅰ) fluorescent dyes designed to assist in intraoperative navigation. These dyes enhance the precision of surgical interventions and contribute to better patient outcomes.

Product name CAS item number
Indocyanine Green, dye content 90% 3599-32-4 593562
Methylene Blue trihydrate, for bio 7220-79-3 468333

 

Professor Yang Youjun’s scientific research achievements | EC series near-infrared fluorescent dyes - high fluorescence intensity and good photostability

EC835, 97%, Near-infrared fluorescent dye, liposoluble

 

Product name CAS Item number
EC835-Br, 97%, Near-infrared fluorescent dye, liposoluble
EC835-Br
/ 9372074
EC835-N3, 97%, Near-infrared fluorescent dye, liposoluble
EC835-N3
/ 9372075
EC835WS, 97%, Near-infrared fluorescent dye, water-soluble
EC835WS
/ 9189162
EC835-WSN3, 97%, Near-infrared fluorescent dye, water-soluble
EC835-WSN3
/ 9372077

 

Indocyanine green (ICG) reactive derivatives—near-infrared I-region fluorescent dyes that can modify and label biological macromolecules

The main application areas of ICG and its derivatives include:

(1) ophthalmic angiography;

(2) perfusion diagnosis of tissues and organs;

(3) sentinel lymph node biopsy of tumors;

(4) near-infrared fluorescence/photoacoustic dual-modal imaging;

(5) Photodynamic/photothermal therapy synergistic treatment[1-4]


J&K Scientific provides 15 kinds of indocyanine green (ICG) active derivatives - which can modify and label biological macromolecules with a purity of ≥95%.

Product name CAS Item number
ICG-COOH, 95% 181934-09-8 9148080
ICG-Maleimide, 95% 2143933-81-5 9148082
ICG-Tetrazine, 95% / 9148083
ICG-azide, 95% / 9148084
ICG-alkyne, 95% 1622335-41-4 9148085
ICG-DBCO, 95% / 9148086
ICG-CBT, 95% / 9148087
ICG-Amine, 95% 1686147-55-6 9148088
ICG-SH, 95% 2387670-76-8 9148089

References

  1. [1]Yunxue Xu, Renfu Liu, Kun xu, Zhifei Dai. Fluorescent Probes for Intraoperative Navigation[J]. Progress in Chemistry, 2021, 33(1): 52-65.
By Vicky Zhao

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